681465-96-3Relevant articles and documents
Terephthalamide peptidomimetic compounds and methods
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Page/Page column 2; sheet 3, (2010/11/27)
The present invention relates to compounds and pharmaceutical compositions based upon terephthalamide which are proteomimetic and to methods for inhibiting the interaction of an alpha-helical protein with another protein or binding site. Methods for treat
Terephthalamide derivatives as mimetics of the helical region of Bak peptide target Bcl-xL protein
Yin, Hang,Hamilton, Andrew D.
, p. 1375 - 1379 (2007/10/03)
A group of novel Bcl-xL/Bak antagonists, based on a terephthalamide scaffold, were designed to mimic the α-helical region of the Bak peptide. Good in vitro inhibition potencies in disrupting the Bak/Bcl-xL complex have been observed (terephthalamide 4, K