852065-42-0Relevant articles and documents
Terephthalamide derivatives as mimetics of helical peptides: Disruption of the Bcl-xL/Bak interaction
Yin, Hang,Lee, Gui-In,Sedey, Kristine A.,Rodriguez, Johanna M.,Wang, Hong-Gang,Sebti, Said M.,Hamilton, Andrew D.
, p. 5463 - 5468 (2007/10/03)
A series of Bcl-xL/Bak antagonists, based on a terephthalamide scaffold, was designed to mimic the α-helical region of the Bak peptide. These molecules showed favorable in vitro activities in disrupting the Bcl-xL/Bak BH3 domain comp