68164-04-5

Basic information

• Product Name: Benzenepropanamine, a-methyl-N-(phenylmethyl)-
• CAS NO: 68164-04-5
• Molecular Formula: C17H21N
• Molecular Weight: 239.36
• Mol File: 68164-04-5.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Benzenepropanamine, a-methyl-N-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanamine, a-methyl-N-(phenylmethyl)-(68164-04-5)
• EPA Substance Registry System: Benzenepropanamine, a-methyl-N-(phenylmethyl)-(68164-04-5)

Safety Data

• Hazardous Substances Data: 68164-04-5(Hazardous Substances Data)

Usage

General Description

Benzenepropanamine, a-methyl-N-(phenylmethyl)-, also known as amphetamine, is a central nervous system stimulant that is used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. It works by increasing the release of certain neurotransmitters in the brain, including dopamine and norepinephrine, which helps to improve focus, attention, and alertness. It is also sometimes used off-label as a performance-enhancing drug or for recreational purposes due to its stimulating and euphoric effects. However, its misuse can lead to addiction, tolerance, and potentially serious side effects, such as increased heart rate, high blood pressure, and psychosis. It is classified as a Schedule II controlled substance in the United States due to its high potential for abuse and addiction.

Upstream product

• 83167-23-1 Benzyl-[1-methyl-3-phenyl-prop-(E)-ylidene]-amine 
• 2550-26-7 4-Phenyl-2-butanone 
• 18720-46-2 benzylamine hydrogenperchlorate 
• 22374-89-6 (RS)-1-methyl-3-phenylpropylamine 
• 100-52-7 benzaldehyde 
• 1353675-02-1 (3-hydroperoxy-3-methoxybutyl)benzene 
• 100-46-9 benzylamine 
• 74-89-5 methylamine 
• 109-73-9 N-butylamine 

Downstream Products

• 81760-40-9 5-[1-Hydroxy-2-(1-methyl-3-phenyl-propylamino)-ethyl]-2-methyl-benzenesulfonamide 
• 344754-64-9 5-{2-[Benzyl-(1-methyl-3-phenyl-propyl)-amino]-acetyl}-2-propyl-benzenesulfonamide 
• 1380487-91-1 N-benzyl-N-methyl-4-phenylbutan-2-amine 
• 81580-34-9 (S)-α-methylbenzenepropanamine hydrochloride 
• 826-16-4 (+)-(R)-α-methylbenzenepropanamine hydrochloride 
• 1332828-01-9 (S)-2,2,2-trifluoro-N-(4-phenylbutan-2-yl)acetamide 
• 4187-57-9 (S)-1-methyl-3-phenylpropylamine 
• 937-52-0 (R)-1-methyl-3-phenylpropylamine 
• 1260510-57-3 C₁₀H₁₀O₄*C₁₇H₂₁N 
• 68504-99-4 2-amino-5-[1-hydroxy-2-[N-(1-methyl-3-phenylpropyl)-N-(phenylmethyl)amino]ethyl]benzenesulphonamide 
• 32780-63-5 2-hydroxy-5-<acetyl>benzamide hydrochloride 
• 76805-38-4 1-(4-ethoxycarbonylmethylphenoxy)-3-(1-methyl-3-phenylpropylamino)-2-propanol 
• 85275-99-6 2-Hydroxy-5-[1-hydroxy-2-(1-methyl-3-phenyl-propylamino)-ethyl]-benzenesulfonamide; hydrochloride 
• 345948-58-5 5-{2-[Benzyl-(1-methyl-3-phenyl-propyl)-amino]-1-hydroxy-ethyl}-2-hydroxy-benzenesulfonamide 

Relevant articles and documents

Intramolecular C?H Amination of N-Alkylsulfamides by tert-Butyl Hypoiodite or N-Iodosuccinimide

1,3-Diamines are an important class of compounds that are broadly found in natural products and are also widely used as building blocks in organic synthesis. Although the intramolecular C?H amination of N-alkylsulfamide derivatives is a reliable method for the construction of 1,3-diamine structures, the majority of these methods involve the use of a transition-metal catalyst. We herein report on a new transition-metal-free method using tert-butyl hypoiodite (t-BuOI) or N-iodosuccinimide (NIS), enabling secondary non-benzylic and tertiary C?H amination reactions to proceed. The cyclic sulfamide products can be easily transformed into 1,3-diamines. Mechanistic investigations revealed that amination reactions using t-BuOI or NIS each proceed via different pathways.

CATALYST COMPOUNDS

The present invention relates to an iridium-based catalyst compound for hydrogenating reducible moieties, especially imines and iminiums, the catalyst compounds being defined by the formulas: where ring B is either itself polycyclic, or ring B together with R is polycyclic. The catalysts of the invention are particularly effective in reductive amination procedures 10 which involve the in situ generation of the imine or iminium under reductive hydrogenative conditions.

CATALYST COMPOUNDS

The present invention relates to an iridium-based catalyst compound for hydrogenating reducible moieties, especially imines and iminiums, the catalyst compounds being defined by the formulas: where ring B is either itself polycyclic, or ring B together with R is polycyclic. The catalysts of the invention are particularly effective in reductive amination procedures 10 which involve the in situ generation of the imine or iminium under reductive hydrogenative conditions.