81580-34-9

Basic information

• Product Name: (S)-α-methylbenzenepropanamine hydrochloride
• Synonyms: (S)-α-methylbenzenepropanamine hydrochloride
• CAS NO: 81580-34-9
• Molecular Weight: 185.697
• Mol File: 81580-34-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (S)-α-methylbenzenepropanamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-α-methylbenzenepropanamine hydrochloride(81580-34-9)
• EPA Substance Registry System: (S)-α-methylbenzenepropanamine hydrochloride(81580-34-9)

Safety Data

• Hazardous Substances Data: 81580-34-9(Hazardous Substances Data)

Upstream product

• 4187-57-9 (S)-1-methyl-3-phenylpropylamine 
• 83167-23-1 Benzyl-[1-methyl-3-phenyl-prop-(E)-ylidene]-amine 
• 73839-93-7 1-methyl-3-phenylpropylamine hydrochloride 
• 68164-04-5 N-benzyl-1-methyl-3-phenylpropylamine 
• 22374-89-6 (RS)-1-methyl-3-phenylpropylamine 
• 911372-76-4 (R_S)-2-methyl-N-((S)-4-phenylbutan-2-yl)propane-2-sulfinamide 
• 2550-26-7 4-Phenyl-2-butanone 
• 911372-54-8 (R_S)-2-methyl-N-(4-phenylbutan-2-ylidene)propane-2-sulfinamide 

Relevant articles and documents

Evolution of titanium(IV) alkoxides and Raney Nickel for asymmetric reductive amination of prochiral aliphatic ketones

(Chemical Equation Presented) A new method for the one-pot asymmetric reductive amination of prochiral aliphatic ketones has been developed. The previously unexplored reagent combination of Ti(OiPr) 4/Raney Ni/H2 in the pr

Sequential reductive amination-hydrogenolysis: A one-pot synthesis of challenging chiral primary amines

Difficult-to-access chiral primary amines were formed in good to high yield and ee using a rare example of a one-pot synthesis from prochiral ketones (sequential reductive amination-hydrogenloysis). As a highlight we also demonstrate a one-pot reductive amination-hydrogenolysis-reductive amination (five reactions) of ortho-methoxyacetophenone resulting in the chiral diamine 1-(2-methoxyphenyl)ethyl-(2-pyridylmethyl)-amine (4) (58% overall yield, >99% ee), a new organocatalyst for aqueous enantioselective aldol reactions. Copyright

SYNTHESIS OF AMINE STEREOISOMERS

The invention relates to methods for producing secondary and tertiary amine diastereomers and corresponding enantiopure or enantioenriched primary or secondary chiral amine products.