68223-20-1

Basic information

• Product Name: (2-hydroxyphenyl)(4-nitrophenyl)methanone
• Synonyms: (2-hydroxyphenyl)(4-nitrophenyl)methanone
• CAS NO: 68223-20-1
• Molecular Weight: 243.219
• Mol File: 68223-20-1.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: (2-hydroxyphenyl)(4-nitrophenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2-hydroxyphenyl)(4-nitrophenyl)methanone(68223-20-1)
• EPA Substance Registry System: (2-hydroxyphenyl)(4-nitrophenyl)methanone(68223-20-1)

Safety Data

• Hazardous Substances Data: 68223-20-1(Hazardous Substances Data)

Upstream product

• 1429-05-6 phenyl 4-nitrobenzoate 
• 122-04-3 4-nitro-benzoyl chloride 
• 103-73-1 Phenetole 
• 116748-53-9 2-formylphenyl 4-nitrobenzenesulfonate 
• 89-95-2 2-methyl-benzyl alcohol 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 42495-50-1 (2-methoxyphenyl)(4-nitrophenyl)methanone 
• 555-16-8 4-nitrobenzaldehdye 
• 108-95-2 phenol 
• 1144-74-7 4-nitrobenzophenone 
• 90-02-8 salicylaldehyde 
• 586-78-7 para-nitrophenyl bromide 
• 636-98-6 p-nitrobenzene iodide 
• 62256-41-1 2-(4-nitrophenoxy)benzaldehyde 

Downstream Products

• 606-12-2 4-[(2-hydroxyphenyl)carbonyl]phenol 
• 42495-50-1 (2-methoxyphenyl)(4-nitrophenyl)methanone 
• 1279131-14-4 (S)-2-((4-nitrophenyl)((3,4,5-trimethoxyphenyl)amino)methyl)phenol 
• 1279130-91-4 (E)-2-((4-nitrophenyl)((3,4,5-trimethoxyphenyl)imino)methyl)phenol 
• 1334334-93-8 2-(imino(4-nitrophenyl)methyl)phenol 
• 1334247-25-4 (S)-2-(amino(4-nitrophenyl)methyl)phenol 

Relevant articles and documents

Water-Tolerant ortho-Acylation of Phenols

A metal-free, water-tolerant, and one-pot process for ortho-acylation of phenols promoted by the iodine source/hydrogen peroxide system has been developed. This transformation undergoes ether formation, iodocyclization, C-C bond cleavage, and oxidative hydrolysis in a one-step manner, which is supported by control experiments.

Cu/Ag mediated peroxide-free synthesis of benzoylated naphthol derivatives

A peroxide-free methodology was developed for the synthesis of benzoylated naphthol/phenol derivatives through oxidative deamination reaction performed under aerobic reaction conditions. A synergistic combination of Cu(OTf)2 and Ag2O was used to convert the aminonaphthols and aminophenols to the corresponding benzoylated derivatives. The definite role of atmospheric oxygen to assist the reaction was proved by performing the reaction in the argon atmosphere.

Rhodium-Catalyzed Directing-Group-Assisted Aldehydic C–H Arylations with Aryl Halides

A rhodium-catalyzed general protocol for the directing-group-assisted arylation of aromatic aldehydic C–H bonds was developed. This method involves either hydroxy- or amino-group-directed aldehyde C–H arylation with various aryl halides. A broad synthetic scope for the preparation of 2-hydroxybenzophenones was established with electronically variant salicylaldehydes and aryl halides with chemo- and regioselective possibilities. The developed protocol was also applied in the synthesis of medicinally important 3-salicyloylpyridines in high yields.