68301-11-1

Basic information

• Product Name: 1,5-dimethyl-3-phenyl-1H-1,2,4-triazole
• Synonyms: 1,5-dimethyl-3-phenyl-1H-1,2,4-triazole
• CAS NO: 68301-11-1
• Molecular Weight: 173.217
• Mol File: 68301-11-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1,5-dimethyl-3-phenyl-1H-1,2,4-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-dimethyl-3-phenyl-1H-1,2,4-triazole(68301-11-1)
• EPA Substance Registry System: 1,5-dimethyl-3-phenyl-1H-1,2,4-triazole(68301-11-1)

Safety Data

• Hazardous Substances Data: 68301-11-1(Hazardous Substances Data)

Upstream product

• 3213-91-0 3-phenyl-5-methyl-<1.2.4>triazole 
• 74-88-4 methyl iodide 
• 40994-01-2 N-methyl-benzamidrazone 
• 95642-85-6 C₁₀H₁₃N₃ 
• 95642-86-7 C₁₁H₁₅N₃ 
• 75-36-5 acetyl chloride 
• 85636-46-0 N-methyl-N-(phenylsulfonyl)benzamidrazone 
• 20205-73-6 N-Acetylbenzimidsaeure-ethylester 
• 60-34-4 methylhydrazine 
• 85636-43-7 N-methyl-N-(phenylsulfonyl)benzohydrazonoyl chloride 
• 75-05-8 acetonitrile 
• 13466-29-0 1-benzylidene-2-methylhydrazine 
• 64-19-7 acetic acid 
• 1198-98-7 5-methyl-3-phenyl-1,2,4-oxadiazole 

Relevant articles and documents

Synthesis of multi-substituted 1,2,4-triazoles utilising the ambiphilic reactivity of hydrazones

The synthesis of N-alkyl-1H-1,2,4-triazoles from N,N-dialkylhydrazones and nitriles via formal [3+2] cycloaddition including the C-chlorination/nucleophilic addition/cyclisation/dealkylation sequence was developed. This sequential reaction utilising the in situ generation of hydrazonoyl chloride based on the ambiphilic reactivity of hydrazones afforded a variety of multi-substituted N-alkyl-triazoles in high yields. The synthetic utility of multi-substituted triazoles was also demonstrated by further transformations.

Photoinduced molecular rearrangements. The photochemistry of some 1,2,4-oxadiazoles in the presence of nitrogen nucleophiles. Formation of 1,2,4-triazoles, indazoles, and benzimidazoles

The photochemistry of some 3,5-disubstituted 1,2,4-oxadiazoles in the presence of nitrogen nucleophiles [external, such as added amines or hydrazines, or internal, such as an o-aminophenyl moiety at C(3) of the oxadiazole ring] has been investigated. In the irradiation of 5-amino-(or 5-N-substituted amino) 3-phenyl-1,2,4-oxadiazoles in the presence of aliphatic primary amines (or ammonia), photolytic species arising from heterolytic cleavage of the ring O-N bond capture the nucleophilic reagent to give open-chain intermediates, which develop into 1,2,4-triazolin-5-ones. Similarly, irradiations of 3,5-diphenyl-, 3-methoxy-5-phenyl-, and 5-methyl-3-phenyl-1,2,4-oxadiazoles gave 1,2,4-triazoles. In the same context, irradiations of representative substrates in the presence of hydrazines have been also investigated. In the irradiation of 3-(o-aminophenyl)-5-methyl-, 3-[o-(methylamino)phenyl]-5-methyl-, and 3-(o-aminophenyl)-5-phenyl-1,2,4-oxadiazoles, concomitant formation of indazoles and benzimidazoles, presumably arising from a common photolytic species, has been observed. Some mechanistic aspects have been considered, and possible applications in synthesis have been pointed out.

N-Methyl-N-(phenylsulfonyl)benzohydrazonoyl Chloride as a Potential Intermediate for Nitrogen-heterocycles. Preparation of 1-Methyl-3-phenyl-1H-1,2,4-triazoles and -pyrazoles

3,5-Disubstituted 1-methyl-1H-1,2,4-triazoles and -pyrazoles were obtained in good to moderate yields by the reaction of N-methyl-N-(phenylsulfonyl)benzohydrazonoyl chloride with nitriles and with acetylenes in the presence of aluminum chloride.The triazo