6850-35-7Relevant articles and documents
Synthesis of trans-3-substituted cyclohexylamines via Br?nsted acid catalyzed and substrate-mediated triple organocatalytic cascade reaction
Zhou, Jian,List, Benjamin
, p. 2037 - 2040 (2007)
We report a new organocatalytic cascade reaction. A combination of the amine substrate with a catalytic amount of a Br?nsted acid merges enamine and iminium catalysis with Br?nsted acid catalysis in a new organocatalytic cascade reaction. We found that the aniline substrate itself in combination with a catalytic amount of PTSA·H2O can function as an aminocatalyst accomplishing an aldol condensation-conjugate reduction cascade, which terminates in a Br?nsted acid catalyzed reductive amination incorporating the amine substrate into the final product. This transformation furnishes trans-3-substituted cyclohexyl amines in good yields and good diastereoselectivities. Georg Thieme Verlag Stuttgart.
Amino-Modified Silica-Supported Copper-Palladium Alloy. Synthesis and Use in Selective Hydrogenation of Disubstituted Nitroarenes in a Flow Micro Reactor
Nurmukhametova,Belov,Sultanova,Vorob’ev,Osin, Yu. N.,Burilov,Antipin
, p. 1 - 6 (2019/04/27)
A copper-palladium catalyst supported on amino-modified silica has been synthesized by chemical reduction. It has been found that submicron particles of a copper-palladium alloy are formed on the silica surface. Unlike commercially available palladium catalysts (Pd/Al2O3, Pd/C, Pd/BaSO4), the synthesized copper-palladium catalyst makes it possible to selectively reduce the nitro group in 3-nitrobenzaldehyde and 1-chloro-4-nitrobenzene.
Asymmetric Amination of Secondary Alcohols by using a Redox-Neutral Two-Enzyme Cascade
Chen, Fei-Fei,Liu, You-Yan,Zheng, Gao-Wei,Xu, Jian-He
, p. 3838 - 3841 (2016/01/26)
Multienzyme cascade approaches for the synthesis of optically pure molecules from simple achiral compounds are desired. Herein, a cofactor self-sufficient cascade protocol for the asymmetric amination of racemic secondary alcohols to the corresponding chiral amines was successfully constructed by employing an alcohol dehydrogenase and a newly developed amine dehydrogenase. The compatibility and the identical cofactor dependence of the two enzymes led to an ingenious in situ cofactor recycling system in the one-pot synthesis. The artificial redox-neutral cascade process allowed the transformation of racemic secondary alcohols into enantiopure amines with considerable conversions (up to 94 %) and >99 % enantiomeric excess at the expense of only ammonia; this method thus represents a concise and efficient route for the asymmetric synthesis of chiral amines. If you know what amine: A redox-neutral two-enzyme cascade encompassing an alcohol dehydrogenase (ADH) and an amine dehydrogenase (AmDH) is constructed for the synthesis of chiral amines from the corresponding racemic alcohols in one pot to afford considerable conversions (up to 94 %) and high enantiomeric excess values (>99 %) at the expense of only ammonia.