685543-88-8Relevant articles and documents
Aza-Peptide Michael Acceptors: A New Class of Inhibitors Specific for Caspases and Other Clan CD Cysteine Proteases
Ekici, ?zlem Do?an,G?tz, Marion G.,James, Karen Ellis,Li, Zhao Zhao,Rukamp, Brian J.,Asgian, Juliana L.,Caffrey, Conor R.,Hansell, Elizabeth,Dvo?ák, Jan,McKerrow, James H.,Potempa, Jan,Travis, James,Mikolajczyk, Jowita,Salvesen, Guy S.,Powers, James C.
, p. 1889 - 1892 (2007/10/03)
Aza-peptide Michael acceptors are a new class of irreversible inhibitors that are highly potent and specific for clan CD cysteine proteases. The aza-Asp derivatives were specific for caspases, while aza-Asn derivatives were effective legumain inhibitors. Aza-Lys and aza-Orn derivatives were potent inhibitors of gingipain K and clostripain. Aza-peptide Michael acceptors showed no cross reactivity toward papain, cathepsin B, and calpain.