686349-59-7

Basic information

• Product Name: 2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-
• CAS NO: 686349-59-7
• Molecular Formula: C14H15N3O5
• Molecular Weight: 305.29
• Mol File: 686349-59-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-(686349-59-7)
• EPA Substance Registry System: 2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-(686349-59-7)

Safety Data

• Hazardous Substances Data: 686349-59-7(Hazardous Substances Data)

Upstream product

• 26391-06-0 2-cyano-N,N-diethylacetamide 
• 116313-85-0 3,4-dihydroxy-5-nitrobenzaldehyde 

Downstream Products

• 145195-63-7 (2Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide 
• 130929-57-6 entacapone 

Relevant articles and documents

Efficient approach to pure entacapone and related compounds

A new and efficient process through a new intermediate, (2E)-2-cyano-3-(3,4-dihydroxy-5-nirtrophenyl)prop-2-enoic acid 15, has been described for preparing substantially pure entacapone 1. This new intermediate 15 was prepared by Knoevenagel condensation of 3,4-dihydroxy-5-nitrobenzaldehyde 2 with 2-cyanoacetic acid 14 and was further condensed with diethylamine to get pure entacapone 1. Some of the important process-related impurities of entacapone (17, 18, 19, and 20) were also prepared easily from this intermediate 15. Copyright Taylor & Francis Group, LLC.