6873-55-8

Basic information

• Product Name: 4-METHYL-BENZENESULFINAMIDE
• Synonyms: 4-METHYL-BENZENESULFINAMIDE;4-Toluenesulfinamide;N-(4-Methylphenyl)sulfinylamine
• CAS NO: 6873-55-8
• Molecular Formula: C₇H₉NOS
• Molecular Weight: 155.22
• Mol File: 6873-55-8.mol
• Article Data: 20

Chemical Properties

• Melting Point: 118-121 °C(lit.)
• Boiling Point: 322.4±35.0 °C(Predicted)
• Appearance: /
• Density: 1.28±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.52±0.40(Predicted)
• CAS DataBase Reference: 4-METHYL-BENZENESULFINAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-BENZENESULFINAMIDE(6873-55-8)
• EPA Substance Registry System: 4-METHYL-BENZENESULFINAMIDE(6873-55-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 6873-55-8(Hazardous Substances Data)

Usage

General Description

4-Methyl-benzenesulfinamide is a chemical compound that belongs to the class of sulfinamides. It is a white, crystalline solid that is commonly used as a reagent in organic synthesis. 4-METHYL-BENZENESULFINAMIDE contains a sulfinyl group attached to a benzene ring with a methyl group substituent. It is often utilized as a building block in the production of pharmaceuticals, agrochemicals, and other fine chemicals due to its versatility and reactive nature. Additionally, 4-methyl-benzenesulfinamide has been evaluated for its potential use as a chiral ligand in asymmetric catalysis, making it an important compound in the field of organic chemistry.

Upstream product

• 10439-23-3 4-methylbenzenesulfinyl chloride 
• 22865-49-2 4-methyl-4'-nitro-diphenyl sulphoxide 
• 89244-06-4 C₁₃H₁₂N₂O₃S 
• 672-78-6 methyl p-toluene sulfinate 
• 847980-35-2 N-chloroacetyl-p-toluenesulfinamide 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 103-19-5 di(p-tolyl) disulfide 
• 536-57-2 p-toluene sulfinic acid 
• 98-59-9 p-toluenesulfonyl chloride 
• 22865-48-1 4-nitrophenyl 4-methylphenyl sulfide 
• 106-45-6 para-thiocresol 
• 657-84-1 sodium tosylate 
• 930-69-8 sodium thiophenolate 

Downstream Products

• 17071-08-8 N-(p-Toluolsulfonyl)-N'-(p-toluolsulfenyl)-schwefeldiimid 
• 13630-85-8 N-Butyl-N'-(p-toluolsulfinyl)harnstoff 
• 103-19-5 di(p-tolyl) disulfide 
• 882-33-7 diphenyldisulfane 
• 243671-40-1 N-dihydrocinnamoyl-p-toluenesulfinamide 
• 70-55-3 toluene-4-sulfonamide 
• 68-34-8 phenyl toluenesulfonamide 
• 77944-40-2 1-Methyl-6-(p-Toluenesulfinyl)cyclohexene 
• 77944-39-9 2-(p-Toluenesulfinyl)methylene-cyclohexane 
• 77944-37-7 1-cyclohexen-1-ylmethyl p-tolyl sulfoxide 

Relevant articles and documents

Hydroxylamine-Derived Reagent as a Dual Oxidant and Amino Group Donor for the Iron-Catalyzed Preparation of Unprotected Sulfinamides from Thiols

An iron catalyzed reaction for the selective transformation of thiols (-SH) to sulfinamides (-SONH2) by a direct transfer of -O and free -NH2 groups has been developed. The reaction operates under mild conditions using a bench stable hydroxylamine derived reagent, exhibits broad functional group tolerance, is scalable and proceeds without the use of any precious metal catalyst or additional oxidant. This novel, practical reaction leads to the formation of two distinct new bonds (S=O and S?N) in a single step to chemoselectively form valuable, unprotected sulfinamide products. Preliminary mechanistic studies implicate the role of the alcoholic solvent as an oxygen atom donor.

2-AMINO-N-(AMINO-OXO-ARYL-LAMBDA6-SULFANYLIDENE)ACETAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 2-amino-N-(amino-oxo-aryl-λ6- sulfanylidene)acetamide compounds (referred to herein as ANASIA compounds) that, inter alia, inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase (aaRS) (e.g., bacterial leucyl-tRNA synthetase, LeuRS). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase; to treat disorders that are ameliorated by the inhibition (e.g., selective inhibition) of bacterial aminoacyl-tRNA synthetase; to treat bacterial infections; etc.

Silicon-Free SuFEx Reactions of Sulfonimidoyl Fluorides: Scope, Enantioselectivity, and Mechanism

SuFEx reactions, in which an S?F moiety reacts with a silyl-protected phenol, have been developed as powerful click reactions. In the current paper we open up the potential of SuFEx reactions as enantioselective reactions, analyze the role of Si and outline the mechanism of this reaction. As a result, fast, high-yielding, “Si-free” and enantiospecific SuFEx reactions of sulfonimidoyl fluorides have been developed, and their mechanism shown, by both experimental and theoretical methods, to yield chiral products.