687966-22-9Relevant articles and documents
Tropane derivatives useable in particular for in vivo detection of dopamine transporters
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, (2008/06/13)
The present invention relates to tropane derivatives having particular use for the in vivo detection of dopamine transporters.These derivatives meet the formula in which R1 is I or Sn (R3)3, R2 is for example the methyl group, and X and Y are various substituents.The derivatives with X=CH3 and Y=H show strong specificity for the dopamine transporter compared with the serotonin transporter (74% inhibition when the transporter is previously saturated with GBR 12909).
Tropane derivatives with selective binding to the serotonin reuptake transporters for treatment of mental illness and as intermediates in the formation of imaging diagnostic agents for depression
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, (2008/06/13)
Biologically active derivatives of the tropane ring system are provided which selectively bind either to the 5-HT or DA reuptake site, leading to compounds which have use for the treatment of clinical depression, attention deficit disorder, obesity and co
N-hydroxypyridine-2-thione carbamates. V. Syntheses of alkaloid skeletons by aminium cation radical cyclizations
Newcomb, Martin,Marquardt, Donald J.,Deeb, Thomas M.
, p. 2329 - 2344 (2007/10/02)
The title radical precursors (PTOC carbamates) were employed as sources of a variety of 5,6-unsaturated aminium cation radicals. 5-Exo radical cyclization followed by trapping by t-BuSH or the PTOC carbamate gave a variety of aklaloid skeletons, typically in good to excellent yields, including pyrrolidines, perhydroindoles, pyrrolizidines, tropanes, 9-azabicyclo[4.2.1]nonanes, 6-azabicyclo [3.2.1]octanes. 6-Exo and 7-endo cyclizations competed in a 6,7-unsaturated system.