69045-78-9Relevant articles and documents
Synthesis, characterization and crystal structure of 2,3,6-trichloro-5- (trichloromethyl)pyridine
Zhu, Xue-Mei,Cai, Zhao-Sheng,Zhang, Huai-Hong,Sun, Ming-Zhu
, p. 110 - 112 (2014)
2,3,6-Trichloro-5-(trichloromethyl)pyridine (TCTCMP) was synthesized from 2-chloro-5-chloromethyl pyridine (CCMP) through two-steps chloridization using chlorine as chlorizating agent. Initially, 2-chloro-5-chloromethyl pyridine was chloridized for 8 h at reflux conditions in the presence of ultraviolet and transformed into 2-chloro-5-(trichloromethyl)pyridine (CTCMP), then CTCMP was chloridized for 6 h at 175 °C with WCl6 as catalyst. The product was characterized by FT-IR, NMR and elemental analysis. The crystal structure of TCTCMP was investigated using X-ray diffraction and SHELXTL97 software and the result indicated that TCTCMP crystallized in the orthorhombic system, space group Pbcm with a = 8.3100(17), b = 17.018 (3), c = 7.3160(15) A, V = 1034.6 (4) A3; Z 4.
2-chloro-5-trichloromethyl pyridine rectification purification method and device
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Paragraph 0019-0030, (2019/10/17)
The invention discloses a 2-chloro-5-trichloromethyl pyridine rectification purification method and device. Rectification purification of 2-chloro-5-trichloromethyl pyridine is implemented by using adevice for rectification purification of 2-chloro-5-trichloromethyl pyridine. By adopting the device for rectification purification of the 2-chloro-5-trichloromethyl pyridine, purification of a crudeproduct of 2-chloro-5-trichloromethyl pyridine can be efficiently implemented, the device is simple in structure and low in cost, and together with a purification method for the crude product of the 2-chloro-5-trichloromethyl pyridine, the purification rate of the crude product of the 2-chloro-5-trichloromethyl pyridine can be greatly increased.
Method for preparing 2, 3, 6-trichloropyridine
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Paragraph 0054; 0055, (2019/05/22)
The invention discloses a preparation method of 2, 3, 6-trichloropyridine. The preparation method comprises the following steps: taking 3-methylpyridine and chlorine as raw materials and preparing 2,3, 6-trichloropyridine through catalytic one-step gas-phase chlorination and trichloromethyl removal by a molecular sieve catalyst in the presence of water vapor. The molecular sieve catalyst is prepared by taking raw molecular sieve powder as an active component. The raw material 3-methylpyridine adopted in the invention is a byproduct in the synthesis of pyridine by an aldehyde ammonia method, and the source is cheap and easy to obtain. The molecular sieve catalyst has strong treatment capacity, the 3-methylpyridine and the chlorine are used as the raw materials, a proper amount of water isadded, gas-phase chlorination and trichloromethyl removal reactions are carried out under the action of a molecular sieve acid center and water vapor molecules, and the 2, 3, 6-trichloropyridine is synthesized by one step. The process is simple, the product purity and conversion rate are high, the yield can be maintained at 85% or above generally, the maximum yield can reach up to 95%, and the preparation method of the 2, 3, 6-trichloropyridine has good industrial application prospect.