69066-32-6

Basic information

• Product Name: ethyl 2-((2-bromophenyl)amino)-2-oxoacetate
• Synonyms: ethyl 2-((2-bromophenyl)amino)-2-oxoacetate
• CAS NO: 69066-32-6
• Molecular Weight: 272.098
• Mol File: 69066-32-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: ethyl 2-((2-bromophenyl)amino)-2-oxoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-((2-bromophenyl)amino)-2-oxoacetate(69066-32-6)
• EPA Substance Registry System: ethyl 2-((2-bromophenyl)amino)-2-oxoacetate(69066-32-6)

Safety Data

• Hazardous Substances Data: 69066-32-6(Hazardous Substances Data)

Upstream product

• 615-36-1 2-bromoaniline 
• 762-21-0 acetylenedicarboxylic acid diethyl ester 
• 4755-77-5 Ethyl oxalyl chloride 

Downstream Products

• 117077-88-0 ethyl(2-bromophenylamino)hydroxyiminoacetate 
• 1251859-41-2 C₁₄H₁₆BrNO₂ 
• 868565-59-7 2-((2-bromophenyl)amino)-2-oxoacetic acid 
• 117077-87-9 ethyl 5-bromo-2-(4-nitrobenzoyl)-1,2,4-benzoxadiazine-3-carboxylate 
• 117077-82-4 ethyl 4-bromobenzo[d]oxazole-2-carboxylate 

Relevant articles and documents

Design, synthesis and biological evaluation of 1-Aryl-5-(4-arylpiperazine-1-carbonyl)-1H-tetrazols as novel microtubule destabilizers

A series of 1-aryl-5-(4-arylpiperazine-1-carbonyl)-1H-tetrazols as microtubule destabilizers were designed, synthesised and evaluated for anticancer activity. Based on bioisosterism, we introduced the tetrazole moiety containing the hydrogen-bond acceptors as B-ring of XRP44X analogues. The key intermediates ethyl 1-aryl-1H-tetrazole-5-carboxylates 10 can be simply and efficiently prepared via a microwave-assisted continuous operation process. Among the compounds synthesised, compound 6–31 showed noteworthy potency against SGC-7901, A549 and HeLa cell lines. In mechanism studies, compound 6–31 inhibited tubulin polymerisation and disorganised microtubule in SGC-7901 cells by binding to tubulin. Moreover, compound 6–31 arrested SGC-7901cells in G2/M phase. This study provided a new perspective for development of antitumor agents that target tubulin.

Visible light-mediated photocatalytic oxidative cleavage of activated alkynes: Via hydroamination: A direct approach to oxamates

The direct oxidative cleavage of activated alkynes via hydroamination has been described using organic photocatalyst under visible-light irradiation at room temperature. In this reaction, the single electron oxidation of an in situ formed enamine followed by radical coupling with an oxidant finally delivers the oxamate. The key features of this photocatalytic reaction are the mild reaction conditions, metal-free organic dye as a photocatalyst, and TBHP playing a dual role as O source and for the regeneration of the photocatalyst.

An efficient synthesis of α,α-diallyl carbinols from esters activated with amides via an in-mediated barbier type allylation

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