69304-43-4Relevant articles and documents
Synthesis method for azvudine
-
Paragraph 0082-0084, (2020/11/22)
The invention discloses a synthesis method for azvudine. The method comprises the following steps of carrying out a hydroxyl substitution reaction on a compound 4 and an iodine elementary substance toobtain a compound 5, carrying out an elimination reaction on an iodo group in the compound 5 to obtain a compound 6, reacting the compound 6 with azide under the catalysis of ICl to obtain a compound7, carrying out an iodine substitution reaction on the compound 7 and carboxylic acid to obtain a compound 8, and carrying out an amino and hydroxyl deprotection reaction on the compound 8 to obtaina compound 9, namely the alzvudine. Compared with an existing synthesis method, the synthesis method has the advantages of short synthesis route, shortened reaction time, mild reaction conditions andeasily controlled reaction process, can be used for preparing the alzvudine with the lower cost, and has a very good application prospect.
High-yield synthesis method of sofosbuvir and sofosbuvir prepared with method
-
Paragraph 0030, (2016/11/07)
The invention relates to a high-yield synthesis method of sofosbuvir and sofosbuvir prepared with the method. The method comprises steps as follows: (a) cytidine and benzoic anhydride are dissolved in a first organic solvent for a reaction; TIDPSCl2 is ad
An azidomethyl protective group in the synthesis of oligoribonucleotides by the phosphotriester method
Efimov,Aralov,Fedunin,Klykov,Chakhmakhcheva
scheme or table, p. 250 - 253 (2010/04/06)
A rapid and effective method of an automatic oligoribonucleotide synthesis alternative to the phosphoramidite one was developed. This method is based on the phosphotriester approach to internucleotide bond formation under intramolecular O-nucleophilic cat