69321-29-5Relevant articles and documents
Synthesis of new 7-substituted 4-methylcoumarin derivatives of antimicrobial activity
Eid,Ragab,El-Ansary,El-Gazayerly,Mourad
, p. 211 - 213 (1994)
New cyclic derivatives derived from 4-methyl-7-coumarinyloxyacetic acid hydrazide have been synthesized. Some representative examples were screened for antimicrobial activity.
Access to new antimicrobial 4-methylumbelliferone derivatives
Zayane, Marwa,Romdhane, Anis,Daami-Remadi, Mejda,Jannet, Hichem Ben
, p. 1619 - 1626 (2015/12/01)
Synthesis of some novel coumarin esters has been accomplished through iodine-catalyzed method using 4-methylumbelliferone as the starting material. Condensation of hydrazide, which was obtained in two steps from 4-methylumbelliferone, with some arylaldhydes provided hydrazone derivatives, while the reaction with phenylthioisocyanate leads to the thiosemicarbazide that evolved into two new compounds. Finally, condensation reaction of hydrazide with three diketones afforded new pyrrole and pyrazole derivatives. Structures of all synthesized compounds were established on the basis of spectroscopic methods including 1H NMR, 13C NMR and ES-HRMS. They were finally tested for their antimicrobial activity and the structure-activity relationship was discussed.
Design and synthesis of some new 1,3,4-thiadiazines with coumarin moieties and their antioxidative and antifungal activity
Cacic, Milan,Pavic, Valentina,Molnar, Maja,Sarkanj, Bojan,Has-Schoen, Elizabeta
, p. 1163 - 1177 (2014/02/14)
A series of newly disubstituted (compounds 4a,b) and trisubstituted 1,3,4-thiadiazines 5a-l with various substituents was prepared utilizing different thiosemicarbazides and 3-A-bromoacetylcoumarins as starting compounds. The structures of the synthesized
