69560-70-9Relevant articles and documents
Choline Chloride Based Deep Eutectic Solvents as a Tuneable Medium for Synthesis of Coumarinyl 1,2,4-Triazoles: Effect of Solvent Type and Temperature
Molnar, Maja,Peri?, Ivana,Komar, Mario
, p. 2688 - 2694 (2019/04/10)
A study of 1,2,4-triazole synthesis from 2-((4-methyl-2-oxo-2H-chromen-7-yl)oxy)acetohydrazide (1) or 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetohydrazide (2) and various isothiocyanates, in deep eutectic solvents, was performed. In order to find the best conditions for 1,2,4-triazole formation, a model reaction on 1 and phenylisothiocyanate was performed in 14 different choline chloride based deep eutectic solvents, at two different temperatures (40 °C and 80 °C). Pure 1,2,4-triazoles were obtained in choline chloride/urea (1:2) and choline chloride/N-methyl urea (1:3) deep eutectic solvents at 80 °C. Pure thiosemicarbazides were obtained in choline chloride/ethane-1,2-diol (1:2), choline chloride/malic acid (1:1), choline chloride/malonic acid (1:1), choline chloride/butane-1,4-diol (1:3) and choline chloride/glycerole (1:2) at 40 °C. The ratio of 1,2,4-triazoles and thiosemicarbazides in reaction mixtures was determined by HPLC and 1H NMR. After the best conditions for 1,2,4-triazole synthesis were found, some coumarinyl 1,2,4-triazoles were synthesized from two different coumarinyl hydrazides (1 and 2) and various alkyl and aryl isothiocyanates in one step reaction.
Synthesis and Biological Activity of 1-(4-Methyl-2-oxo-2H-1-benzopyran-7-yloxoacetyl)-4-alkylthiosemicarbazides, -1,3,4-thiadiazoles and -1,2,4-triazoles
Eltamany,El-Deen,El-Fattah, M. F. Abd
, p. 367 - 369 (2007/10/03)
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Synthesis and Biological Activity of 1-(4-Methyl-2-oxo-2H-benzopyran-7-yloxoacetyl)-4-alkylthiosemicarbazides: 1,3-Thiadiazoles and 1,2,4-Triazoles
Eltamany, S. H.,El-Deen, I. M.,El-Fattah, M. E. Abd
, p. 115 - 118 (2007/10/03)
A series of 1-(4-methyl-2-oxo-2H-1-benzopyran-7-yloxoacetyl)-4-alkylthiosemicarbazides, S-triazoles and their methyl derivatives has been synthesized by condensation of 4-methyl-2-oxo-2H-1-benzopyran-7-yloxo-acetyl hydrazine with alkyl isothiocyanates.Subsequent ring closure of the substituted thiosemicarbazides yielded the S-triazoles and reaction with methyl iodide gave the corresponding methyl derivatives.The substituted 1,3,4-thiadiazoles have been synthesized by cyclodehydration of the substituted thiosemicarbazides with phosphoric acid.The biological activity of some new compounds is reported. - Key Words: Substituted 1,3,4-Thiadiazoles; 1,2,4-Triazoles; Biological activity.