6947-57-5

Basic information

• Product Name: (cyclohexylsulfonyl)benzene
• CAS NO: 6947-57-5
• Molecular Formula: C₁₂H₁₆O₂S
• Molecular Weight: 224.3192
• Mol File: 6947-57-5.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 386.7°C at 760 mmHg
• Flash Point: 229°C
• Density: 1.157g/cm³
• Vapor Pressure: 7.74E-06mmHg at 25°C
• Refractive Index: 1.545
• CAS DataBase Reference: (cyclohexylsulfonyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (cyclohexylsulfonyl)benzene(6947-57-5)
• EPA Substance Registry System: (cyclohexylsulfonyl)benzene(6947-57-5)

Safety Data

• Hazardous Substances Data: 6947-57-5(Hazardous Substances Data)

Usage

Description

(Cyclohexylsulfonyl)benzene, also known as toluene sulfinic acid, is a chemical compound that consists of a benzene ring with a sulfonyl group attached to a cyclohexyl group. It is a colorless liquid that is used as an intermediate in the synthesis of various organic compounds.

Uses

Used in Organic Synthesis:
(Cyclohexylsulfonyl)benzene is used as a reagent in organic synthesis for the preparation of sulfonyl chlorides and sulfonyl fluorides. Its versatile properties make it an important compound in this field.
Used in Pharmaceutical Production:
(Cyclohexylsulfonyl)benzene is used as an intermediate in the production of pharmaceuticals, contributing to the development of new medications.
Used in Agrochemical Production:
(Cyclohexylsulfonyl)benzene is also utilized as an intermediate in the production of agrochemicals, which are essential for the agricultural industry.
Used in Specialty Chemicals Production:
(Cyclohexylsulfonyl)benzene is used as an intermediate in the production of other specialty chemicals, highlighting its significance in various industrial applications.

Upstream product

• 7570-92-5 cyclohexyl phenyl sulphide 
• 103979-48-2 1,1-bis(phenylsulphonyl)cylohexane 
• 129855-23-8 (6-Bromo-hex-1-ene-2-sulfonyl)-benzene 
• 98-88-4 benzoyl chloride 
• 105494-85-7 1-phenylsulfonyl-1-trimethylsilylcyclohexane 
• 139177-27-8 Allyl-(1-benzenesulfonyl-cyclohexyl)-dimethyl-silane 
• 137384-82-8 1-bromo-1-phenylsulfonyl cyclohexane 
• 22651-87-2 cyclohexanecarboxylic acid anhydride 
• 626-62-0 Cyclohexyl iodide 
• 98-86-2 acetophenone 
• 2525-55-5 (prop-2-ene-1,2-diyldisulfonyl)dibenzene 
• 109-64-8 1,3-dibromo-propane 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 3324-82-1 (phenylsulfinyl)cyclohexane 

Downstream Products

• 68826-45-9 Acetic acid 1-(1-benzenesulfonyl-cyclohexyl)-2-cyclohexylidene-ethyl ester 
• 68826-50-6 Acetic acid 1-(1-benzenesulfonyl-cyclohexyl)-2-[2-methylene-cyclohex-(Z)-ylidene]-ethyl ester 
• 68826-49-3 Acetic acid (E)-1-(1-benzenesulfonyl-cyclohexyl)-3-phenyl-allyl ester 
• 68826-51-7 Benzoic acid 1-(1-benzenesulfonyl-cyclohexyl)-heptyl ester 
• 133828-01-0 1-trimethylsilyl-2-(1'-benzenesulfonyl-cyclohexyl)-ethanol 
• 105494-85-7 1-phenylsulfonyl-1-trimethylsilylcyclohexane 
• 112177-39-6 1-phenylsulfonyl-1-(2-methoxy-2-propenyl)cyclohexane 
• 74254-66-3 1-(phenylsulfonyl)cyclohexanecarboxylic acid 
• 114764-23-7 [2-(1-Benzenesulfonyl-cyclohexylsulfanyl)-ethyl]-trimethyl-silane 
• 137384-82-8 1-bromo-1-phenylsulfonyl cyclohexane 
• 137384-83-9 (1-Iodo-cyclohexanesulfonyl)-benzene 
• 112177-38-5 1-phenylsulfonyl-1-benzylcyclohexane 
• 137345-43-8 1-cyclohexyloxomethyl-1-(phenylsulfonyl)cyclohexane 
• 137345-42-7 1-cyclohexylhydroxymethyl-1-(phenylsulfonyl)cyclohexane 

Relevant articles and documents

Reductive Lithiation of Bis-Phenylsulfones

Reductive cleavage of geminal bis-phenylsulfones using lithium naphthalenide in THF at -78 degC selectively affords α-sulfonyl carbanions which participate in typical reaction with electrophiles. - Key words: desulfonylation, lithium naphthalenide, alkyla

Method for synthesizing sulfone compounds under photocatalysis condition

The invention belongs to the technical field of compound preparation, and particularly relates to a method for synthesizing sulfone compounds under a photocatalysis condition. Aromatic hydrazine and sulfinate are used as raw materials, and under the action of alkali and a solvent, a sulfone compound is generated through reaction under the condition of air or oxygen under the illumination of visible light. According to the method disclosed by the invention, aryl hydrazine is used as an arylation reagent, polyacid salt is used as a catalyst or an organic photosensitizer is used as a catalyst, and the sulfones compound can be efficiently synthesized by coupling with sulfinate under the condition of room temperature through visible light irradiation. The method has good substrate universalityand relatively mild reaction conditions, is not only a substitute for synthesizing sulfone compounds by coupling from simple substrates reported at present, but also broadens the new application of the polyacid salt in the field of photocatalysis.

Iron-catalyzed cross-coupling of unactivated secondary alkyl thio ethers and sulfones with aryl grignard reagents

The first systematic investigation of unactivated aliphatic sulfur compounds as electrophiles in transition-metal-catalyzed cross-coupling are described. Initial studies focused on discerning the structural and electronic features of the organosulfur substrate that enable the challenging oxidative addition to the C(sp3)-S bond. Through extensive optimization efforts, an Fe(acac)3-catalyzed cross-coupling of unactivated alkyl aryl thio ethers with aryl Grignard reagents was realized in which a nitrogen "directing group" on the S-aryl moiety of the thio ether served a critical role in facilitating the oxidative addition step. In addition, alkyl phenyl sulfones were found to be effective electrophiles in the Fe(acac) 3-catalyzed cross-coupling with aryl Grignard reagents. For the latter class of electrophile, a thorough assessment of the various reaction parameters revealed a dramatic enhancement in reaction efficiency with an excess of TMEDA (8.0 equiv). The optimized reaction protocol was used to evaluate the scope of the method with respect to both the organomagnesium nucleophile and sulfone electrophile.