695171-91-6

Basic information

• Product Name: 4-(tert-butyloxycarbonylamino)phenylacetaldehyde
• Synonyms: 4-(tert-butyloxycarbonylamino)phenylacetaldehyde;tert-butyl N-[4-(2-oxoethyl)phenyl]carbamate;TERT-BUTYL (4-(2-OXOETHYL)PHENYL)CARBAMATE
• CAS NO: 695171-91-6
• Molecular Formula: C₁₃H₁₇NO₃
• Molecular Weight: 235
• Mol File: 695171-91-6.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(tert-butyloxycarbonylamino)phenylacetaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(tert-butyloxycarbonylamino)phenylacetaldehyde(695171-91-6)
• EPA Substance Registry System: 4-(tert-butyloxycarbonylamino)phenylacetaldehyde(695171-91-6)

Safety Data

• Hazardous Substances Data: 695171-91-6(Hazardous Substances Data)

Upstream product

• 104060-23-3 tert-butyl N-[4-(2-hydroxyethyl)phenyl]carbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 104-10-9 2-(4'-aminophenyl)ethyl alcohol 
• 112918-77-1 methyl 2-(4-((tert-butoxycarbonyl)amino)phenyl)acetate 
• 5438-70-0 ethyl (4-amino-3,5-dibromophenyl)acetate 
• 897648-31-6 ethyl 2-(4-((tert-butoxycarbonyl)amino)phenyl)acetate 
• 104-03-0 4-nitrobenzeneacetic acid 
• 5445-26-1 ETHYL 4-NITROPHENYLACETATE 

Downstream Products

• 695171-95-0 diphenyl 1-benzyloxycarbonylamino-2-(4-(tert-butyloxycarbonylamino)phenyl)ethanephosphonate 
• 913239-30-2 di-(4-acetamidophenyl)-1-(benzyloxycarbonylamino)-2-(4-tert-butyloxycarbonylaminophenyl)ethanephosphonate 
• 913239-29-9 diphenyl 1-amino-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate 
• 934622-38-5 benzyl 1-(bis(4-acetamidophenoxy)phosphoryl)-2-(4-amino-phenyl)ethylcarbamate 
• 695172-02-2 diphenyl 1-(benzyloxycarbonylamino)-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate 
• 934622-42-1 di(4-acetamidophenyl) 1-amino-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate 
• 913239-31-3 di-(4-acetamidophenyl) 1-(benzyloxycarbonylamino)-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate 
• 913239-50-6 C₄₆H₅₉N₆O₁₁PS 
• 913239-47-1 diphenyl 1-[(N-benzoyl-O-tert-butyl-D-seryl)-L-alanyl]amino-2-[4-(N,N'-bis(tert-butyloxycarbonyl)guanidino)phenyl]ethanephosphonate 
• 913239-45-9 diphenyl 1-[(benzenesulfonyl-O-tert-butyl-D-seryl)-L-alanyl]amino-2-[4-(N,N'-bis(tert-butyloxycarbonyl)guanidino)phenyl]ethanephosphonate 
• 913239-49-3 diphenyl 1-[(N-2-thiophenesulfonyl-O-tert-butyl-D-seryl)-L-alanyl]amino-2-[4-(N,N'-bis(tert-butyloxycarbonyl)guanidino)phenyl]ethanephosphonate 
• 913239-56-2 diphenyl 1-[(N-m-methylbenzoyl-O-tert-butyl-D-seryl)-L-alanyl]amino-2-[4-(N,N'-bis(tert-butyloxycarbonyl)guanidino)phenyl]ethanephosphonate 
• 913239-57-3 diphenyl 1-[(N-o-methylbenzoyl-O-tert-butyl-D-seryl)-L-alanyl]amino-2-[4-(N,N'-bis(tert-butyloxycarbonyl)guanidino)phenyl]ethanephosphonate 
• 913239-46-0 C₄₈H₆₃N₆O₁₂PS 

Relevant articles and documents

CONJUGATE OF MONOMETHYL AURISTATIN F AND TRASTUZUMAB AND ITS USE FOR THE TREATMENT OF CANCER

The present invention relates to an antibody-drug-conjugate or pharmaceutical composition comprising the same. From one aspect, the invention relates to an antibody-drug-conjugate (ADC) comprising an antibody consisting of the Trastuzumab or a biosimilar thereof, said antibody being conjugated to at least one drug consisting of a monomethyl auristatin F derivative. The invention also comprises method of treatment of cancer comprising administering to the subject an effective amount of said antibody-drug-conjugate or composition comprising the same.

CONJUGATE OF MONOMETHYL AURISTATIN F AND TRASTUZUMAB AND ITS USE FOR THE TREATMENT OF CANCER

The present invention relates to an antibody-drug-conjugate. From one aspect, the invention relates to an antibody-drug-conjugate comprising an antibody consisting of the Trastuzumab, said antibody being conjugated to at least one drug consisting of a monomethyl auristatin F derivative. The invention also comprises method of treatment and the use of said antibody-drug-conjugate for the treatment of cancer.

ANTIBODY-DRUG-CONJUGATE AND ITS USE FOR THE TREATMENT OF CANCER

The present invention relates to an antibody-drug-conjugate. From one aspect, the invention relates to an antibody-drug-conjugate comprising an antibody capable of binding to a Target, said antibody being conjugated to at least one drug selected from derivatives of dolastatin 10 and auristatins. The invention also comprises method of treatment and the use of said antibody-drug-conjugate for the treatment of cancer.