934622-42-1Relevant articles and documents
Novel Urokinase Inhibitors
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Page/Page column 34-36, (2009/01/24)
The present invention relates to novel compounds with inhibitory activity towards urokinase plasminogen activator (uPA); to methods for preparation of said uPA inhibitor compounds; to pharmaceutical compositions comprising said uPA inhibitor compounds; to
Diphenyl phosphonate inhibitors for the urokinase-type plasminogen activator: Optimization of the P4 position
Joossens, Jurgen,Van Der Veken, Pieter,Surpateanu, Georgiana,Lambeir, Anne-Marie,El-Sayed, Ibrahim,Ali, Omar M.,Augustyns, Koen,Haemers, Achiel
, p. 5785 - 5793 (2007/10/03)
This paper describes the structure-activity relationship in a series of tripeptidyl diphenyl phosphonate irreversible urokinase plasminogen activator (uPA) inhibitors, originally derived from an arginyltripeptide. uPA is considered an interesting target i