69559-11-1

Basic information

• Product Name: 2-(4-Aminopentyl(ethyl)amino)ethanol
• Synonyms: HYDROXYNOVOLDIAMINE;2-(4-aminopentyl(ethyl)amino)ethanol;5-(N-ETHYL-N-2-ETHOXYLAMINO)-2-PENTYL AMINE;5-(N-Ethyl-N-2-hydroxyethylamino)-2-penthlamine;5-(N-ETHYL-N-2-HYDROXYETHYLAMINO)-2-PENTLAMINE;4-AMINO-N-ETHYL-(2-HYDROXYETHYL)-PENTYLAMINE;HYDROXYNOVOLDIAMINE,5-(N-ETHYL-N-2-HYDROXYETHYLAMINO)-2-PENTHLAMINE;N-Ethyl-N-hydroxyethyl-1,4-pentamethylene diamine
• CAS NO: 69559-11-1
• Molecular Formula: C₉H₂₂N₂O
• Molecular Weight: 174.28
• EINECS: 274-039-9
• Mol File: 69559-11-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 263.6 °C at 760 mmHg
• Flash Point: 113.2 °C
• Appearance: /
• Density: 0.935
• Vapor Pressure: 0.00143mmHg at 25°C
• Refractive Index: 1.470-1474
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 14.76±0.10(Predicted)
• CAS DataBase Reference: 2-(4-Aminopentyl(ethyl)amino)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Aminopentyl(ethyl)amino)ethanol(69559-11-1)
• EPA Substance Registry System: 2-(4-Aminopentyl(ethyl)amino)ethanol(69559-11-1)

Safety Data

• Hazardous Substances Data: 69559-11-1(Hazardous Substances Data)

Usage

Uses

2-(4-Aminopentyl(ethyl)amino)ethanol is a colorless and pure liquid that can be used as a pharmaceutical intermediate.

InChI:InChI=1/C9H22N2O/c1-3-11(7-8-12)6-4-5-9(2)10/h9,12H,3-8,10H2,1-2H3

Upstream product

• 74509-79-8 5-(N-ethyl-N-2-hydroxyethylamine)-2-pentanone 
• 3695-29-2 5-iodo-2-pentanone 
• 517-23-7 3-acetyl-2-oxo-4,5-dihydrofuran 
• 159346-86-8 R(-)-5--2-pentanamine 

Downstream Products

• 137433-23-9 (R)-Hydroxychloroquine 
• 137433-23-9 (S)-Hydroxychloroquine 
• 118-42-3 hydroxychloroquine 
• 747-36-4 Plaquenil 
• 747-36-4 (S)-hydroxychloroquine sulfate 
• 747-36-4 R-(-)-hydroxychloroquine sulfate 

Relevant articles and documents

Method for continuously producing 5-(N-ethyl-N-2-hydroxyethyl amine)-2-pentylamine

The invention discloses a method for continuously producing 5-(N-ethyl-N-2-hydroxyethyl amine)-2-pentylamine, and the method comprises the following steps: in a reducing atmosphere, continuously inputting a mixed solution containing 5-(N-ethyl-N-2-hydroxyethyl amine)-2-pentanone and a nitrogen source into a fixed bed reactor filled with a supported nano nickel-based catalyst; carrying out reductive amination reaction under the conditions that the pressure is 0.2 to 2MPa, the temperature is 80 to 140 DEG C and the feeding mass space velocity is 0.2 to 1.0 h , so as to prepare the 5-(N-ethyl-N-2-hydroxyethyl amine)-2-pentylamine. According to the method provided by the invention, the continuous production of the 5-(N-ethyl-N-2-hydroxyethyl amine)-2-pentylamine can be realized under theaction of the supported nano Ni catalyst and a nitrogen source; meanwhile, the catalyst is low in cost, high in production efficiency, good in stability, simple to operate, low in production cost andconvenient for industrial production.

HIGH-YIELDING CONTINUOUS FLOW SYNTHESIS OF ANTIMALARIAL DRUG HYDROXYCHLOROQUINE

Cost effective, semi-continuous flow methods and systems for synthesizing the antimalarial drug hydroxychloroquine (HCQ) in high yield are provided. The synthesis method that uses simple, inexpensive reagents to obtain the crucial intermediate 5-(ethyl(2-hydroxyethyl)- amino)pentan-2-one, vertical-integration of the starting material 5-iodopentan-2-one and the integration of continuous stirred tank reactors.