69583-00-2

Basic information

• Product Name: 2-Pyridin-4-ylacetohydrazide
• Synonyms: 2-Pyridin-4-ylacetohydrazide;2-pyridin-4-ylacetohydrazide(SALTDATA: FREE);4-Pyridineacetic acid hydrazide
• CAS NO: 69583-00-2
• Molecular Formula: C₇H₉N₃O
• Molecular Weight: 151.17
• Product Categories: Pyridines
• Mol File: 69583-00-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 85-86 °C(Solv: benzene (71-43-2))
• Boiling Point: 416.8 °C at 760 mmHg
• Flash Point: 205.9 °C
• Appearance: /
• Density: 1.208 g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 12.38±0.37(Predicted)
• CAS DataBase Reference: 2-Pyridin-4-ylacetohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridin-4-ylacetohydrazide(69583-00-2)
• EPA Substance Registry System: 2-Pyridin-4-ylacetohydrazide(69583-00-2)

Safety Data

• Hazardous Substances Data: 69583-00-2(Hazardous Substances Data)

Usage

General Description

2-Pyridin-4-ylacetohydrazide is a chemical compound with the molecular formula C8H10N4O. It is a derivative of hydrazine and is commonly used as a building block in the synthesis of various pharmaceutical and agrochemical products. The compound is a white to light yellow solid that is sparingly soluble in water and soluble in organic solvents. It is a versatile reagent in organic synthesis due to its ability to undergo various chemical transformations, such as condensation reactions and nucleophilic additions. 2-Pyridin-4-ylacetohydrazide is also known to exhibit antitumor and antibacterial activities, making it a valuable compound in medicinal chemistry research.

Upstream product

• 29800-89-3 methyl 4-pyridineacetate 
• 54401-85-3 pyridin-4-yl-acetic acid ethyl ester 
• 39178-35-3 isonicotinoyl chloride hydrochloride 
• 586-95-8 pyridine-4-methanol 
• 1822-51-1 4-picolylchloride hydrochloride 
• 13121-99-8 pyridin-4-ylacetonitrile 

Downstream Products

• 101284-85-9 [4]pyridyl-acetic acid trans-cinnamylidenehydrazide 
• 101435-11-4 [4]pyridyl-acetic acid-(3-phenyl-propylidenehydrazide) 
• 110157-00-1 [4]pyridyl-acetic acid-(2-chloro-benzylidenehydrazide) 
• 101281-51-0 [4]pyridyl-acetic acid-(4-acetylamino-benzylidenehydrazide) 
• 92166-26-2 pyridin-4-yl-acetic acid benzylidenehydrazide 
• 100867-80-9 [4]pyridyl-acetic acid-(4-hydroxy-benzylidenehydrazide) 
• 101091-56-9 [4]pyridyl-acetic acid-(4-methoxy-benzylidenehydrazide) 
• 19731-15-8 [4]pyridyl-acetic acid salicylidenehydrazide 
• 101091-70-7 [4]pyridyl-acetic acid vanillylidenehydrazide 
• 92852-22-7 [4]pyridyl-acetic acid-(1-phenyl-ethylidenehydrazide) 
• 173599-02-5 4-pyridylacetylbenzamidrazone 
• 173598-99-7 3⁽⁵⁾-phenyl-5⁽³⁾-(4-pyridylmethyl)-1,2,4-triazole 
• 83417-26-9 3-amino-5-(4-pyridylmethyl)-1,2,4-triazole 
• 1320340-15-5 C₁₅H₁₆N₄O₂ 

Relevant articles and documents

The syntheses of isotopically labelled CB-1 antagonists for the treatment of obesity

BMS-725519, BMS-811064, and BMS-812204 are potent and selective central cannabinoid receptor antagonists that have been investigated for the treatment of human obesity. To further understand their biotransformation profiles, radiolabelled and stable-labelled products were required. This paper describes the utility of [14C]1,1-carbonyldiimidazole as a radiolabelling reagent for the syntheses of carbonyl-labelled [14C]BMS-725519, [14C]BMS-811064, and [14C]BMS-812204. The syntheses of stable-labelled [13C6]BMS-725519 and [13CD3 13CD2]BMS-812204 synthesized from of [13C6]4-chloroacetophenone and [13CD3 13CD2]iodoethane, respectively, are also described.

Synthesis, in vitro screening and docking studies of new thiosemicarbazide derivatives as antitubercular agents

A series of thiosemicarbazide derivatives was designed and synthesized by reaction of carboxylic acid hydrazide with isothiocyanates. The molecular structures of the investigated thiosemicarbazides were confirmed and characterized by spectroscopic analysis. The conformational preference of carbonylthiosemicarbazide chain and intra- and intermolecular interactions in the crystalline state were characterized using X-ray analysis. The antituberculosis activity of the target compounds were tested in vitro against four Mycobacterium strains: M. H37Ra, M. phlei, M. smegmatis, M. timereck. The most active compounds were those with 2-pyridine ring. They exhibited lower minimal inhibitory concentration (MIC) values in the range 7.81–31.25 μg/mL in comparison to the other isomers. Compound 5 had activity against M. smegmatis at a concentration of 7.81 μg/mL whereas compound 2 had activity against all tested strains at a concentration of 15.625 μg/mL. The molecular docking studies were performed for investigated compounds using the Mycobacterium tuberculosis glutamine synthetase MtGS as their molecular target.

Synthesis, experimental and theoretical study on the structure of some semicarbazides with potential antibacterial activity

A series of 1,4-disubstituted semicarbazide and 4,4'-bis[1-substituted semicarbazide]diphenyl-methane derivatives were synthesized to explore their antibacterial activity. New compounds were characterized by elemental analysis and spectroscopic data. In order to find the tautomeric equilibrium for the molecules energy calculations for each possible tautomeric form of model compound 2, and for the most antibacterially active compound 7 in the investigated series, were calculated for the gas phase at the RHF/SCF/6-31G** level of theory.