6959-79-1

Basic information

• Product Name: 1-(3-O-acetyl-5-S-acetyl-2-deoxy-5-thiopentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
• CAS NO: 6959-79-1
• Molecular Formula: C₁₄H₁₈N₂O₆S
• Molecular Weight: 342.3675
• Mol File: 6959-79-1.mol
• Article Data: 1

Chemical Properties

• Density: 1.39g/cm³
• Refractive Index: 1.581
• CAS DataBase Reference: 1-(3-O-acetyl-5-S-acetyl-2-deoxy-5-thiopentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-O-acetyl-5-S-acetyl-2-deoxy-5-thiopentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione(6959-79-1)
• EPA Substance Registry System: 1-(3-O-acetyl-5-S-acetyl-2-deoxy-5-thiopentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione(6959-79-1)

Safety Data

• Hazardous Substances Data: 6959-79-1(Hazardous Substances Data)

Usage

General Description

The chemical 1-(3-O-acetyl-5-S-acetyl-2-deoxy-5-thiopentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione is a complex molecule consisting of a pyrimidine base linked to a pentofuranosyl sugar. It contains acetyl and thiol groups attached to the sugar and a methyl group attached to the pyrimidine moiety. 1-(3-O-acetyl-5-S-acetyl-2-deoxy-5-thiopentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione belongs to the class of nucleoside analogs and is potentially used in the development of antiviral or anticancer drugs due to its ability to interfere with nucleic acid synthesis. However, further research is needed to fully understand the potential biological activities of this compound.

Upstream product

• 14046-57-2 3'-O-acetyl-5'-deoxy-5'-iodothymidine 
• 34832-35-4 sodium thioacetate 
• 21090-30-2 3'-O-acetylthymidine 
• 59211-00-6 3'-O-Acetyl-5'-O-mesyl-thymidin 

Downstream Products

• 7150-83-6 5'-thio-thymidine 

Relevant articles and documents

5'-S-NUCLEOSIDE TRIPHOSPHATES. SYNTHESIS AND SUBSTRATE PROPERTIES IN TESTS WITH DNA POLYMERASES

With the aim of studying the properties of DNA polymerases in the biosynthesis of DNA we have synthesized the 5'-S-triphosphates of 5'-mercapto-5'-deoxythymidine and of 5'-mercapto-3',5'-dideoxythymidine from 3'-O-acetylthymidine and 3'-deoxythymidine, respectively.A study in cell-free systems with DNA polymerases of the triphosphate compounds obtained showed that 5'-mercapto-5'-deoxythymidine 5'-S-triphosphate possessed weak substrate properties, being included only once in the 3'-end of a growing DNA chain when the process was catalyzed by DNA polymerase I and AMV reverse transcriptase.At the same time, neither DNA polymerase α from human placenta, nor DNA polymerase β from rat liver, nor HIV reverse transcriptase interacted with these compounds at all. 5'-Mercapto-3',5'-dideoxythymidine 5'-triphosphate did not extend a DNA chain on catalysts by any of the above-mentioned enzymes.Possible reason for the sharp fall in the substrate properties of the compounds synthesized as compared with the natural substrates of DNA polymerases are discussed.