7150-83-6

Basic information

• Product Name: 1-(2-deoxy-5-thiopentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
• CAS NO: 7150-83-6
• Molecular Formula: C₁₀H₁₄N₂O₄S
• Molecular Weight: 258.2942
• Mol File: 7150-83-6.mol
• Article Data: 5

Chemical Properties

• Density: 1.408g/cm³
• Refractive Index: 1.593
• CAS DataBase Reference: 1-(2-deoxy-5-thiopentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-deoxy-5-thiopentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione(7150-83-6)
• EPA Substance Registry System: 1-(2-deoxy-5-thiopentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione(7150-83-6)

Safety Data

• Hazardous Substances Data: 7150-83-6(Hazardous Substances Data)

Usage

General Description

1-(2-deoxy-5-thiopentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione, also known as 5-Methylthio-5-deoxy-D-ribose-1,5-bisphosphate, is a chemical compound with potential antiviral and anticancer properties. It is a modified nucleoside analog that can inhibit viral replication by interfering with the synthesis of viral DNA or RNA. 1-(2-deoxy-5-thiopentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione has shown promising results in inhibiting the replication of certain viruses, including HIV and herpes simplex virus. Additionally, it has demonstrated potential in inhibiting the growth of certain cancer cells. Research on the therapeutic potential of this compound is ongoing, and it may hold promise for the development of new antiviral and anticancer treatments.

Upstream product

• 84364-98-7 2-[(2S,3S,5R)-3-Hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-isothiourea; hydriodide 
• 6959-79-1 3'-O-acetyl-5'-acetylthio-5'-deoxythymidine 
• 174466-94-5 Thiobenzoic acid S-[(2S,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester 
• 132628-15-0 9-(4-methoxyphenyl)-9H-xanthene-9-thiol 
• 144944-94-5 5'-S-acetyl-5'-deoxy-5'-thiothymidine 
• 7253-19-2 5'-O-(p-toluenesulfonyl)thymidine 
• 50-89-5 thymidine 
• 14046-57-2 3'-O-acetyl-5'-deoxy-5'-iodothymidine 
• 21090-30-2 3'-O-acetylthymidine 
• 59211-00-6 3'-O-Acetyl-5'-O-mesyl-thymidin 
• 25953-14-4 1-((2R,4S,5S)-4-hydroxy-5-(iodomethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 

Downstream Products

• 84364-97-6 5'-S-dimethylarsino-5'-thio-5'-deoxythymidine 
• 177738-46-4 5'-S-(4,4'-dimethoxytrityl)-5'-thiothymidine 
• 500775-64-4 5'-S-(4,4'-dimethoxytrityl)-5'-thiothymidine 3'-(2-cyanoethyl-diisopropylphosphoramidite) 
• 144846-10-6 5'-(12-trityloxydodecylthio)-5'-deoxythymidine 
• 167147-55-9 5'-[(3,4-dibenzyloxy)benzylthio]-5'-deoxythymidine 
• 65-71-4 thymin 

Relevant articles and documents

Efficient solid phase synthesis of cleavable oligodeoxynucleotides based on a novel strategy for the synthesis of 5′-S-(4,4′-dimethoxytrityl)- 2′-deoxy-5′-thionucleoside phosphoramidites

The incorporation of a specific cleavage site into an oligodeoxynucleotide can be achieved by utilizing the four 5′-S-(4,4′-dimethoxytrityl)- 2′-deoxy-5′-thionucleoside 3′-(2-cyanoethyl diisopropylphosphoramidites) 5 and 15a-c (Fig.1). Based on the silver

Dinucleoside monophosphate analogues containing disulfide linkages

Two dinucleoside monophosphate analogues containing disulfide linkages (1 and 2) have been prepared for incorporation into oligonucleotides. The modified oligomers will be tested for their potential as antisense agents.

Biomolecules bearing the SAsMe2 group: Nucleoside derivatives

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