700816-79-1

Basic information

• Product Name: (2S,3S)-2-amino-3-(4-hydroxyphenyl)-3-methoxypropanoic acid
• Synonyms: (2S,3S)-2-amino-3-(4-hydroxyphenyl)-3-methoxypropanoic acid
• CAS NO: 700816-79-1
• Molecular Weight: 211.218
• Mol File: 700816-79-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2S,3S)-2-amino-3-(4-hydroxyphenyl)-3-methoxypropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S)-2-amino-3-(4-hydroxyphenyl)-3-methoxypropanoic acid(700816-79-1)
• EPA Substance Registry System: (2S,3S)-2-amino-3-(4-hydroxyphenyl)-3-methoxypropanoic acid(700816-79-1)

Safety Data

• Hazardous Substances Data: 700816-79-1(Hazardous Substances Data)

Upstream product

• 871129-50-9 ethyl 3-(4-((2-methoxyethoxy)methoxy)phenyl)-3-oxopropanoate 
• 84775-31-5 1-(4-((2-methoxyethoxy)methoxy)phenyl)ethanone 
• 196092-88-3 (2R)-O-acetyl-3-bromo-N-phthaloyltyrosine methyl ester 
• 160648-53-3 O-acetyl-N-phthaloyl-L-tyrosine methyl ester 
• 1080-06-4 L-Tyr-OMe 
• 39739-09-8 methyl (S)-2-(1,3-dioxoisoindolin-2-yl)-3-(4-hydroxyphenyl)propanoate 
• 863871-24-3 (2S,3S)-3-methoxy-N-phthaloyl-tyrosine methyl ester 
• 188446-23-3 (2R,5S,αS)-5-[4'-benzyloxy-α-hydroxy]benzyl-2,5-dihydro-3,6-dimethoxy-2-isopropylpyrazine 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 864954-42-7 (2R,5S,αS)-5-[4'-benzyloxy-α-methoxy]benzyl-2,5-dihydro-3,6-dimethoxy-2-isopropylpyrazine 
• 865062-12-0 (S)-O-benzyl-β-methoxy-L-tyrosine allyl ester 
• 864954-43-8 (S)-O-benzyl-β-methoxy-L-tyrosine methyl ester 
• 863871-29-8 (2S,3S)-β-methoxytyrosine methyl ester 

Relevant articles and documents

An Efficient Synthesis of Enantiopure (2 R,3 R)-β-Methoxytyrosine

Enantiopure (2R,3R)-β-methoxytyrosine was stereoselectively synthesized from ethyl 3-(4-hydroxyphenyl)-3-oxopropanoate protected by 2-methoxyethoxymethyl (MEM) (ee >98%). l-Aminoacylase-catalyzed resolution of the corresponding erythro-N-acetyl derivatives afforded (2S,3S)-(4-MEM)-β-methoxytyrosine (ee >99%). The conversion increased to 98% by optimizing the synthesis to yield enantiopure N-acetyl-(2R,3R)-(4-MEM)-methoxytyrosine. N-Acyl cleavage was accomplished under mild conditions.

Concise synthesis of all stereoisomers of β-methoxytyrosine and determination of the absolute configuration of the residue in callipeltin A

(Chemical Equation Presented) All stereoisomers of β-methoxytyrosine (β-OMeTyr), a stereo-undefined component of callipeltin A, were synthesized from L- and D-tyrosine. The stereochemistry of β-OMeTyr in callipeltin A was determined to be 2R,3R by an oxidative procedure and Marfey's analysis.