871129-50-9Relevant articles and documents
An Efficient Synthesis of Enantiopure (2 R,3 R)-β-Methoxytyrosine
Fan, Shi-Ming,Tian, Xia,Yang, Yi-Hua,Jin, Long Yi,Liu, Shou-Xin
, p. 2553 - 2556 (2015)
Enantiopure (2R,3R)-β-methoxytyrosine was stereoselectively synthesized from ethyl 3-(4-hydroxyphenyl)-3-oxopropanoate protected by 2-methoxyethoxymethyl (MEM) (ee >98%). l-Aminoacylase-catalyzed resolution of the corresponding erythro-N-acetyl derivatives afforded (2S,3S)-(4-MEM)-β-methoxytyrosine (ee >99%). The conversion increased to 98% by optimizing the synthesis to yield enantiopure N-acetyl-(2R,3R)-(4-MEM)-methoxytyrosine. N-Acyl cleavage was accomplished under mild conditions.