701-45-1

Basic information

• Product Name: 3-Bromo-4-fluoronitrobenzene
• Synonyms: 2-BROMO-1-FLUORO-4-NITROBENZENE;2-FLUORO-5-NITROBROMOBENZENE;3-BROMO-4-FLUORONITROBENZENE;3-Bromo-4-fluoro-1-nitrobenzene;3-BROMO-4-FLUORONITROBENZENE, 98+%;1-Fluoro-2-bromo-4-nitrobenzene;Benzene, 2-broMo-1-fluoro-4-nitro-;2-Bromo-1-fluoro-4-nitrobenzene 95%
• CAS NO: 701-45-1
• Molecular Formula: C₆H₃BrFNO₂
• Molecular Weight: 220
• EINECS: 211-855-6
• Product Categories: blocks;Bromides;FluoroCompounds;NitroCompounds;Fluorinated benzene series
• Mol File: 701-45-1.mol
• Article Data: 19

Chemical Properties

• Melting Point: 55°C
• Boiling Point: 250.6 °C at 760 mmHg
• Flash Point: 105.4 °C
• Appearance: /Solid
• Density: 1.808 g/cm³
• Vapor Pressure: 0.397mmHg at 25°C
• Refractive Index: 1.484
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 3-Bromo-4-fluoronitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-4-fluoronitrobenzene(701-45-1)
• EPA Substance Registry System: 3-Bromo-4-fluoronitrobenzene(701-45-1)

Safety Data

• Hazard Codes: Xi,Xn
• HazardClass: IRRITANT
• Hazardous Substances Data: 701-45-1(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow solid

Uses

Reatant in the synthesis of N-fused tricyclic indoles, dimethyamine, benzofuran.

InChI:InChI=1/C8H7FO2/c1-6(10)11-8-4-2-3-7(9)5-8/h2-5H,1H3

Upstream product

• 350-46-9 4-Fluoronitrobenzene 
• 1072-85-1 o-fluorobromobenzene 
• 369-36-8 6-fluoro-3-nitroaniline 
• 7439-89-6 iron 
• 462-06-6 fluorobenzene 
• 320-98-9 5-fluoro-2-nitrobenzoic acid 

Downstream Products

• 105583-11-7 (2-bromo-4-nitro-phenyl)-phenyl sulfide 
• 656-64-4 3-bromo-4-fluoroaniline 
• 77123-61-6 2-fluoro-5-nitro-1-<(trimethylsilyl)ethynyl>benzene 
• 63989-45-7 2-[(2-Bromo-4-nitro-phenyl)-methyl-amino]-ethanol 
• 63989-43-5 N-Acetyl-β-aminoethyl-2-brom-4-nitro-1-phenylether 
• 853014-35-4 2,2',4'-tribromo-4-nitrodiphenyl ether 
• 425378-68-3 2-(2-fluoro-5-nitrophenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane 
• 945244-26-8 diethyl 2-(2-bromo-4-nitrophenyl)-2-methylmalonate 
• 425379-21-1 5'-bromo-6,2'-difluorobiphenyl-2-carbonitrile 
• 154716-47-9 4-fluoro-3-pyridin-4-yl-phenylamine 
• 154716-46-8 4-(2-fluoro-5-nitro-phenyl)-pyridine 
• 425379-43-7 4-fluoro-3-(3-fluoro-pyridin-2-yl)-phenylamine 
• 425379-88-0 4-fluoro-3-(5-fluoro-pyridin-2-yl)-phenylamine 
• 425379-42-6 3-fluoro-2-(2-fluoro-5-nitro-phenyl)-pyridine 

Relevant articles and documents

Pd-Catalyzed Decarboxylative Ortho-Halogenation of Aryl Carboxylic Acids with Sodium Halide NaX Using Carboxyl as a Traceless Directing Group

A highly regioselective Pd-catalyzed carboxyl directed decarboxylative ortho-C-H halogenation of cheap o-nitrobenzoic acids with NaX (X = I, Br) under aerobic conditions has been established. The utility of the method has been demonstrated by the gram-scale reaction and derivatization of the product. Experimental results have confirmed Pd and Bi played critical roles in the transformation and indicated the transformation might proceed via 2-halo-6-nitrobenzoic acid derivative intermediate.

NITROGENOUS HETEROCYCLIC DERIVATIVES AND THEIR APPLICATION IN DRUGS

The invention relates to the field of medicine, discloses new nitrogen heterocyclic derivatives, preparation method thereof and as medicament in particular as the treatment and prevention of treating tissue fibrosis of the medicament. The invention also discloses a pharmaceutically acceptable compound of the present invention comprise a pharmaceutical composition and methods for using the composition for the treatment of the human or animal tissue fibrosis of diseases, in particular for treating the human or animal renal interstitial fibrosis, glomerular sclerosis, hepatic fibrosis, pulmonary fibrosis, peritoneal fibrosis, myocardial fibrosis, skin fibrosis, after the operation of adhering, benign prostate hypertrophy, bone-myocardial, scleroderma, multiple sclerosis, pancreas fibrosis, liver cirrhosis, myosarcoma, neurofibromatosis, interstitial pulmonary fibrosis, diabetic nephropathy, Alzheimer's disease or vascular fibrosis disease in use. (by machine translation)

Nitrogenous Heterocyclic Derivatives And Their Application In Drugs

The present invention relates to the field of medicine, provided herein are novel nitrogenous heterocyclic compounds, their preparation methods and their uses as drugs, especially for treatment and prevention of tissue fibrosis. Also provided herein are pharmaceutically acceptable compositions comprising the nitrogenous heterocyclic compounds and the uses of the compositions in the treatment of human or animal tissue fibrosis, especially for human or animal renal interstitial fibrosis, glomerular sclerosis, liver fibrosis, pulmonary fibrosis, peritoneal fibrosis, myocardial fibrosis, dermatofibrosis, postsurgical adhesion, benign prostatic hyperplasia, skeletal muscle fibrosis, scleroderma, multiple sclerosis, pancreatic fibrosis, cirrhosis, myosarcoma, neurofibroma, pulmonary interstitial fibrosis, diabetic nephropathy, alzheimer disease or vascular fibrosis.