425379-21-1Relevant articles and documents
SUBSTITUTED IMIDAZOTRIAZINES
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Page/Page column 34-35, (2011/02/24)
This invention relates to novel substituted imidazotriazines and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases
Imidazo[1,2-a]pyrazin-8-ones, imidazo[1,2-d][1,2,4]triazin-8-ones and imidazo[2,1-f][1,2,4]triazin-8-ones as α2/α3 subtype selective GABAA agonists for the treatment of anxiety
Goodacre, Simon C.,Hallett, David J.,Carling, Robert W.,Castro, Jose L.,Reynolds, David S.,Pike, Andrew,Wafford, Keith A.,Newman, Robert,Atack, John R.,Street, Leslie J.
, p. 1582 - 1585 (2007/10/03)
Imidazo[1,2-a]pyrazin-8-ones, imidazo[1,2-d][1,2,4]triazin-8-ones and imidazo[2,1-f][1,2,4]triazin-8-ones are high affinity GABAA agonists. Compound 16d has good oral bioavailability in rat, functional selectivity for the GABAAα2 and
Palladium-catalyzed regioselective arylation of imidazo[1,2-b][1,2,4] triazine: Synthesis of an α2/3-selective GABA agonist
Gauthier Jr., Donald R.,Limanto, John,Devine, Paul N.,Desmond, Richard A.,Szumigala Jr., Ronald H.,Foster, Bruce S.,Volante
, p. 5938 - 5945 (2007/10/03)
A convergent, practical, and efficient synthesis of 2′,6-difluoro- 5′-[3-(1-hydroxy-1-methylethy)-imidazo[1,2-b][1,2,4]triazin-7-yl] biphenyl-2-carbonitrile (1), an orally active GABAA dag-selective agonist, is described. The seven-step, chromatography-fr
