918545-22-9

Basic information

• Product Name: 5'-(8-chloro-imidazo[1,2-a]pyrazin-3-yl)-6,2'-difluoro-biphenyl-2-carbonitrile
• CAS NO: 918545-22-9
• Molecular Weight: 366.757
• Mol File: 918545-22-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5'-(8-chloro-imidazo[1,2-a]pyrazin-3-yl)-6,2'-difluoro-biphenyl-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-(8-chloro-imidazo[1,2-a]pyrazin-3-yl)-6,2'-difluoro-biphenyl-2-carbonitrile(918545-22-9)
• EPA Substance Registry System: 5'-(8-chloro-imidazo[1,2-a]pyrazin-3-yl)-6,2'-difluoro-biphenyl-2-carbonitrile(918545-22-9)

Safety Data

• Hazardous Substances Data: 918545-22-9(Hazardous Substances Data)

Upstream product

• 701-45-1 2-bromo-1-fluoro-4-nitrobenzene 
• 425379-17-5 6,2'-difluoro-5'-nitrobiphenyl-2-carbonitrile 
• 425379-18-6 5'-amino-6,2'-difluorobiphenyl-2-carbonitrile 
• 425378-68-3 2-(2-fluoro-5-nitrophenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane 
• 69214-33-1 8-chloroimidazo[1,2-α]pyrazine 
• 425379-21-1 5'-bromo-6,2'-difluorobiphenyl-2-carbonitrile 
• 143591-61-1 3-bromo-8-chloro-imidazo[1,2-a]pyrazine 
• 425379-22-2 6,2'-difluoro-5'-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile 

Downstream Products

• 918544-48-6 6,2'-difluoro-5'-(8-oxo-7,8-dihydro-imidazo[1,2-a]pyrazin-3-yl)-biphenyl-2-carbonitrile 
• 918545-44-5 6,2'-difluoro-5'-(8-methoxy-imidazo[1,2-a]pyrazin-3-yl)-biphenyl-2-carbonitrile 

Relevant articles and documents

Imidazo[1,2-a]pyrazin-8-ones, imidazo[1,2-d][1,2,4]triazin-8-ones and imidazo[2,1-f][1,2,4]triazin-8-ones as α2/α3 subtype selective GABAA agonists for the treatment of anxiety

Imidazo[1,2-a]pyrazin-8-ones, imidazo[1,2-d][1,2,4]triazin-8-ones and imidazo[2,1-f][1,2,4]triazin-8-ones are high affinity GABAA agonists. Compound 16d has good oral bioavailability in rat, functional selectivity for the GABAAα2 and