701-49-5

Basic information

• Product Name: 4-FLUORO-N-METHYLBENZAMIDE
• Synonyms: 4-FLUORO-N-METHYLBENZAMIDE;N-Methyl 4-fluorobenzamide
• CAS NO: 701-49-5
• Molecular Formula: C₈H₈FNO
• Molecular Weight: 153.1536232
• Product Categories: blocks;Carboxes;FluoroCompounds
• Mol File: 701-49-5.mol
• Article Data: 28

Chemical Properties

• Melting Point: 133-134 °C
• Boiling Point: 276.2 °C at 760 mmHg
• Flash Point: 120.9 °C
• Appearance: /
• Density: 1.142 g/cm³
• Vapor Pressure: 0.00486mmHg at 25°C
• Refractive Index: 1.506
• Storage Temp.: 2-8°C
• PKA: 14.88±0.46(Predicted)
• CAS DataBase Reference: 4-FLUORO-N-METHYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-N-METHYLBENZAMIDE(701-49-5)
• EPA Substance Registry System: 4-FLUORO-N-METHYLBENZAMIDE(701-49-5)

Safety Data

• Hazardous Substances Data: 701-49-5(Hazardous Substances Data)

Usage

General Description

4-Fluoro-N-methylbenzamide is a chemical compound with the molecular formula C8H8FNO. It is a white crystalline solid and is classified as an amide. 4-Fluoro-n-methylbenzamide is commonly used in research and pharmaceutical applications due to its unique properties. It is a derivative of benzamide and contains a fluorine atom at the 4 position and a methyl group attached to the nitrogen atom. 4-Fluoro-N-methylbenzamide has a variety of potential uses in the field of organic synthesis and has been studied for its potential pharmacological activities. Additionally, it may also have applications in the preparation of pharmaceutical intermediates and other chemical compounds.

InChI:InChI=1/C8H8FNO/c1-10-8(11)6-2-4-7(9)5-3-6/h2-5H,1H3,(H,10,11)

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 85462-16-4 N-Methyl-O-p-nitrophenylsulphonylhydroxylamine 
• 403-43-0 4-fluorobenzoyl chloride 
• 74-89-5 methylamine 
• 421-20-5 Methyl fluorosulfonate 
• 1194-02-1 4-fluorobenzonitrile 
• 325980-20-9 N-benzyl-N-methyl-4-fluorobenzamide 
• 116332-54-8 4-fluoro-N-methoxy-N-methylbenzamide 
• 456-22-4 4-Fluorobenzoic acid 
• 593-51-1 methylamine hydrochloride 
• 824-75-9 p-fluorobenzamide 
• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 460-00-4 1-Bromo-4-fluorobenzene 

Downstream Products

• 52893-48-8 Trifluormethyl-p-fluorbenzoat 
• 52893-52-4 4-Fluoro-N-methyl-benzimidic acid ethyl ester 
• 82791-56-8 1-(4-Fluoro-phenyl)-6,7-dimethoxy-2-methyl-2H-isoquinolin-3-one 
• 1067902-24-2 4-(9-Benzyl-3,9-diazaspiro[5.5]undec-3-yl)-N-methylbenzamide 
• 1018569-94-2 N-methyl-4-(piperazin-1-yl)benzamide 
• 1246085-02-8 N-methyl-4-(4-((2-methyl-3-oxo-8-propyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)benzamide 
• 1246085-38-0 N-methyl-4-(4-(2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yloxy)piperidin-1-yl)benzamide 
• 1263407-42-6 N-methyl-4-(4-((6-oxo-5,6-dihydropyrido[2,3-e]pyrrolo[1,2-c]pyrimidin-3-yl)methyl)piperazin-1-yl)benzamide 
• 1261060-39-2 2,6-dibutyl-4-fluoro-N-methylbenzamide 
• 1281888-66-1 2,6-dioctyl-4-fluoro-N-methylbenzamide 
• 1309375-43-6 2,6-diethyl-N-methylbenzamide 
• 1309375-46-9 2,6-diethyl-4-fluoro-N-methylbenzamide 
• 1315257-13-6 6-fluoro-2-methyl-3,4-diphenylisoquinolin-1(2H)-one 
• 1235478-87-1 6-methoxy-2-methyl-3,4-diphenylisoquinolin-1(2H)-one 

Relevant articles and documents

Assemblies of 1,4-Bis(diarylamino)naphthalenes and Aromatic Amphiphiles: Highly Reducing Photoredox Catalysis in Water

Host-guest assemblies of a designed 1,4-bis(diarylamino)naphthalene and V-shaped aromatic amphiphiles consisting of two pentamethylbenzene moieties bridged by an m -phenylene unit bearing two hydrophilic side chains emerged as highly reducing photoredox catalysis systems in water. An efficient demethoxylative hydrogen transfer of Weinreb amides has been developed. The present supramolecular strategy permits facile tuning of visible-light photoredox catalysis in water.

Rhodium-Catalyzed Electrooxidative C?H Olefination of Benzamides

Metal-catalyzed chelation-assisted C?H olefinations have emerged as powerful tools for the construction of functionalized alkenes. Herein, we describe the rhoda-electrocatalyzed C?H activation/alkenylation of arenes. The olefinations of challenging electron-poor benzamides were thus accomplished in a fully dehydrogenative fashion under electrochemical conditions, avoiding stoichiometric chemical oxidants, and with H2 as the only byproduct. This versatile alkenylation reaction also features broad substrate scope and used electricity as a green oxidant.

Rhenium-Catalyzed Phthalide Synthesis from Benzamides and Aldehydes via C-H Bond Activation

The [4 + 1] annulation of benzamides and aldehydes for phthalide synthesis was achieved via rhenium-catalyzed C-H activation, which demonstrates an unprecedented reaction pattern distinct from those of other transition-metal catalyses. The reaction also features readily available starting materials, a wide scope for both electro-rich and electro-deficient substrates, and the elimination of homoannulation byproducts.