70120-14-8

Basic information

• Product Name: 2-BroMo-5-(1,1-diMethylheptyl)phenol
• Synonyms: 2-BroMo-5-(1,1-diMethylheptyl)phenol
• CAS NO: 70120-14-8
• Molecular Formula: C₁₅H₂₃BrO
• Molecular Weight: 299.24652
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 70120-14-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Methanol
• CAS DataBase Reference: 2-BroMo-5-(1,1-diMethylheptyl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BroMo-5-(1,1-diMethylheptyl)phenol(70120-14-8)
• EPA Substance Registry System: 2-BroMo-5-(1,1-diMethylheptyl)phenol(70120-14-8)

Safety Data

• Hazardous Substances Data: 70120-14-8(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellow Oil

Uses

Intermediate in the synthesis of a cannabinoid receptor ligand.

Upstream product

• 70120-12-6 2-(3-hydroxyphenyl)-2-methyloctane 
• 70120-09-1 2-(3-benzyloxyphenyl)-2-methylpropionaldehyde 
• 70120-08-0 2-<3-(benzyloxy)phenyl>-2-methylpropionitrile 
• 70435-82-4 1-Benzyloxy-3-(1,1-dimethyl-2-heptenyl)-benzol 
• 21406-61-1 pentyltriphenylphosphonium bromide 
• 70120-10-4 1-(benzyloxy)-3-(1,1-dimethyl-2-heptenyl)benzene 

Downstream Products

• 70120-16-0 1-bromo-2-benzyloxy-4-(1,1-dimethylheptyl)benzene 
• 70119-99-2 4-<4-(1,1-dimethylheptyl)-2-hydroxyphenyl>-2-pentanone 
• 70434-30-9 3-<4-(1,1-dimethylheptyl)-2-hydroxyphenyl>cyclohexanone 
• 70120-01-3 4-<2-(benzyloxy)-4-(1,1-dimethylheptyl)phenyl>-2-pentanol 
• 70434-13-8 3-<2-(benzyloxy)-4-(1,1-dimethylheptyl)phenyl>cyclohexanone 
• 70120-03-5 4-<4-(1,1-dimethylheptyl)-2-hydroxyphenyl>-2-pentanol 
• 70119-97-0 4-<2-(benzyloxy)-4-(1,1-dimethylheptyl)phenyl>-2-pentanone 
• 70434-83-2 (E)-3-<4-(1,1-dimethylheptyl)-2-hydroxyphenyl>cyclohexanol 
• 70434-82-1 (Z)-3-<4-(1,1-dimethylheptyl)-2-hydroxyphenyl>cyclohexanol 
• 70434-50-3 (E)-3-<2-(benzyloxy)-4-(1,1-dimethylheptyl)phenyl>cyclohexanol 
• 70434-49-0 (Z)-3-<2-(benzyloxy)-4-(1,1-dimethylheptyl)phenyl>cyclohexanol 
• 895131-89-2 VSN₂₈ 
• 895131-93-8 VSN₂₇ 
• 769970-04-9 VSN₁₃ 

Relevant articles and documents

MODULATOR

The present invention relates to a compound of formula I, or a pharmaceutically acceptable salt thereof. Formula (I), wherein R1 and R2 are each independently H or alkyl; Y is an alkyl group. CONR3R4, COOR5SO2NR16R17, NHSO2R18 or CN; X is an aryl or heteroaryl group, each of which may be optionally substituted with one or more substituents selected from (CH2)mZ where Z is halogen, OH, CN, alkyl, alkoxy, NO2, CF3, CONR6R7, CN, NR8R9, COOR10 or NHCOR11 and m is 0 to 3; R3 to R11 are each independently H, alkyl or aryl, wherein said alkyl and aryl groups are optionally substituted by one or more substituents selected from halogen, OH, CN, alkyl, alkoxy, NO2, CF3, CONR12R13, CN, NH2, COOR14, NHCOR15, and CN; R12 to R18 are each independently H or alkyl, more preferably H or Me; n is 1 to 6; wherein the compound is other than 3′,5′-dimethyl-4-(1,1-dimethylheptyl)-1,1′-biphenyl-2-ol. Further aspects of the invention related to the use of such compounds in the preparation of a medicament for the treatment of a muscular disorder, a gastrointestinal disorder, or for controlling spasticity or tremors.

A Cannabinoid Derived Prototypical Analgesic

The synthesis and analgesic testing of 3-cyclohexanol (1) are described.Prior (SAR) studies led us to conclude that the pyran ring of 9-nor-9β-hydroxyhexahydrocannabinol (HHC) was not necessary for the expression of biological activity in this series of cannabinoids.Analysis of models and the use of molecular mechanics calculations suggested that a simpler compound, such as 1, would possess the biological activity of HHC.Compound 1 was prepared in nine steps from acetonitrile (2).Biological testing in five models of pain shows that compound 1 and morphine are equally potent as analgesics and demonstrates that the pyran ring of HHC is not necessary for biological activity.Further simplification of 1 was pursued by the synthesis of 4--2-pentanol (17), but this derivative exhibits significantly reduced analgesic activity.

3-[2-Hydroxy-4-(substituted)phenyl]-cycloalkanol analgesic agents

Cycloalkanones, cycloalkanols and unsaturated analogs thereof, each of which has at the 3-position a 2-hydroxy-4-substituted phenyl group wherein the 4-position substituent is alkyl which can have an oxygen atom as part of the chain, or aralkyl which can have an oxygen atom as part of the alkyl chain, their use for pharmacological and medicinal purposes, intermediates therefor and processes for their preparation.