701261-90-7

Basic information

• Product Name: methyl (R)-2-(methoxymethoxy)-3-phenylpropanoate
• Synonyms: methyl (R)-2-(methoxymethoxy)-3-phenylpropanoate
• CAS NO: 701261-90-7
• Molecular Weight: 224.257
• Mol File: 701261-90-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl (R)-2-(methoxymethoxy)-3-phenylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (R)-2-(methoxymethoxy)-3-phenylpropanoate(701261-90-7)
• EPA Substance Registry System: methyl (R)-2-(methoxymethoxy)-3-phenylpropanoate(701261-90-7)

Safety Data

• Hazardous Substances Data: 701261-90-7(Hazardous Substances Data)

Upstream product

• 146235-25-8 (2R)-2-acetoxy-3-phenylpropanoic acid 
• 13057-17-5 bromethyl methyl ether 
• 27000-00-6 methyl 2-hydroxy-3-phenylpropionate 
• 673-06-3 D-(R)-phenylalanine 
• 828-01-3 D-phenyllactic acid 

Downstream Products

• 701261-77-0 (tert-butoxycarbonylimino-{3-[2-({6-methoxymethoxy-1-[2-(2-methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionyl]-octahydro-indole-2-carbonyl}-amino)-ethyl]-2,5-dihydro-pyrrol-1-yl}-methyl)-carbamic acid tert-butyl ester 
• 701261-96-3 2-tert-butoxycarbonylamino-5-[3-({6-methoxymethoxy-1-[2-(2-methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionyl]-octahydro-indole-2-carbonyl}-amino)-propylidene]-5,6-dihydro-4H-pyrimidine-1-carboxylic acid tert-butyl ester 
• 701261-92-9 (2S,3aS,6R,7aS)-6-Acetoxy-1-[(R)-2-((R)-2-methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionyl]-octahydro-indole-2-carboxylic acid methyl ester 
• 701261-94-1 (2S,3aS,6R,7aS)-6-Methoxymethoxy-1-[(R)-2-((R)-2-methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionyl]-octahydro-indole-2-carboxylic acid 
• 701261-75-8 (2S,3aS,6R,7aS)-6-Methoxymethoxy-1-[(R)-2-((R)-2-methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionyl]-octahydro-indole-2-carboxylic acid methyl ester 
• 701261-93-0 (2S,3aS,6R,7aS)-6-Hydroxy-1-[(R)-2-((R)-2-methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionyl]-octahydro-indole-2-carboxylic acid methyl ester 
• 701261-91-8 (R)-2-((R)-2-Methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid benzyl ester 
• 701261-74-7 (R)-2-((R)-2-Methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid 
• 282551-84-2 MOM-D-phenyllactic acid 

Relevant articles and documents

Total Synthesis of (+)-Prunustatin A: Utility of Organotrifluoroborate-Mediated Prenylation and Shiina MNBA Esterification and Macrolactonization to Avoid a Competing Thorpe-Ingold Effect Accelerated Transesterification

A convergent total synthesis of (+)-prunustatin A is described through the assembly of two key fragments and a macrolactonization. Shiina MNBA couplings were used for the formation of each of the four ester bonds in the tetralactone ring, including the key macrocyclization which was essential to minimize competing Thorpe-Ingold accelerated transesterification. Other key steps included an organoboron-based prenylation using potassium prenyltrifluoroborate and a carbonyldiimidazole-mediated coupling to form the salicylamide.