70132-79-5

Basic information

• Product Name: Methanone, (2-chlorophenyl)(2,5-dimethylphenyl)-
• CAS NO: 70132-79-5
• Molecular Formula: C15H13ClO
• Molecular Weight: 244.721
• Mol File: 70132-79-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Methanone, (2-chlorophenyl)(2,5-dimethylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (2-chlorophenyl)(2,5-dimethylphenyl)-(70132-79-5)
• EPA Substance Registry System: Methanone, (2-chlorophenyl)(2,5-dimethylphenyl)-(70132-79-5)

Safety Data

• Hazardous Substances Data: 70132-79-5(Hazardous Substances Data)

Upstream product

• 22328-43-4 2,5-dimethylbenzoyl chloride 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 118-91-2 ortho-chlorobenzoic acid 
• 106-42-3 para-xylene 
• 16537-16-9 2-chloro-benzoic acid tert-butyl ester 
• 609-65-4 o-chlorobenzoyl chloride 
• 32250-86-5 2-[(2-chlorophenyl)methyl]-1,4-dimethylbenzene 

Downstream Products

• 70132-80-8 3-(2,5-dimethyl-phenyl)-benzo[d]isothiazole 

Relevant articles and documents

Controlled photo-flow oxidative reaction (UV-FOR) platform for ultra-fast phthalide and API synthesis

An integrated photo-flow oxidative reaction (UV-FOR) platform approach is presented for the synthesis of phthalides. The current protocol is catalyst-free, and uses economical and abundant hydro-carbons and hydrocarbon derivatives such as benzoic acid, benzene, and xylene, as starting materials. The reaction is performed using oxygen as a green oxidant in a time- and labour-efficient manner. This integrated approach has been shown to be successful in making a UV-FOR platform suitable for the on-demand synthesis of phthalides and their further syntheses to 2-arylmethylbenzoic acids and arylogous Michael addition products under relatively mild conditions. The current protocol was further extended to the gram scale synthesis of an ischemic stroke-relevant active pharmaceutical ingredient (API), 3-N-butylphthalide (NBP), in a continuous flow process.

Esters as acylating reagent in a Friedel-Crafts reaction: Indium tribromide catalyzed acylation of arenes using dimethylchlorosilane

(Chemical Equation Presented) The Friedel-Crafts acylation of arenes with esters by dimethylchlorosilane and 10 mol % of indium tribromide has been achieved. The key intermediate RCOOSi(Cl)Me2 is generated from alkoxy esters with the evolution of the corresponding alkanes. The scope of the alkoxy ester moiety was wide: tert-butyl, benzyl, allyl, and isopropyl esters were successful. In addition, we demonstrated the direct synthesis of the indanone intermediate 11 of salviasperanol from ester 10.

Antimony(V) chloride-benzyltriethylammonium chloride complex as an efficient catalyst for friedel-crafts acylation reactions

A novel catalytic system, the complex of antimony(V) chloride (SbCl 5) and benzyltriethylammonium chloride (TEBA), C6H 5CH2NEt3(SbCl5)2Cl complex, is described for Friedel-Crafts acylation reactions of aromatics with acyl and sulfonyl chlorides. The catalyst has a number of useful characteristics, such as ready access, minimal toxicity, reusability, insensitivity to atmosphere and moisture, rapid acylation with high yield, and ease of operation.