703-17-3

Basic information

• Product Name: 1-Propanone, 2,2-difluoro-1-phenyl- (9CI)
• Synonyms: 1-Propanone, 2,2-difluoro-1-phenyl- (9CI)
• CAS NO: 703-17-3
• Molecular Formula: C₉H₈F₂O
• Molecular Weight: 170.1560264
• Product Categories: ACETYLHALIDE
• Mol File: 703-17-3.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Propanone, 2,2-difluoro-1-phenyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 2,2-difluoro-1-phenyl- (9CI)(703-17-3)
• EPA Substance Registry System: 1-Propanone, 2,2-difluoro-1-phenyl- (9CI)(703-17-3)

Safety Data

• Hazardous Substances Data: 703-17-3(Hazardous Substances Data)

Upstream product

• 2114-03-6 2,2-dibromo-1-phenylpropan-1-one 
• 673-32-5 1-Phenylprop-1-yne 
• 67-56-1 methanol 
• 93-55-0 1-phenyl-propan-1-one 
• 14210-89-0 (1,2,2-Trifluoro-1-methoxy-propyl)-benzene 
• 30085-70-2 4-(1-phenyl-propenyl)-morpholine 
• 91562-55-9 [1-Phenyl-prop-(E)-ylidene]-propyl-amine 
• 98-86-2 acetophenone 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 126587-15-3 (2,2-difluoro-1-phenylcyclopropoxy)trimethylsilane 
• 4767-01-5 2-methyl-3-oxo-3-phenylpropionic acid 
• 115262-01-6 [bromo(difluoro)methyl]-trimethyl-silane 
• 37471-46-8 1-phenyl-1-trimethylsiloxypropene 

Downstream Products

• 73611-97-9 2,2-Difluoro-1-phenyl-1-propanol 
• 1352954-31-4 (Z)-(2-fluorooct-2-en-3-yl)benzene 
• 1352954-17-6 (E)-(2-fluorooct-2-en-3-yl)benzene 
• 1352954-03-0 (3,3-difluorobut-1-en-2-yl)benzene 

Relevant articles and documents

Bench-Stable Electrophilic Fluorinating Reagents for Highly Selective Mono- and Difluorination of Silyl Enol Ethers

Efficient methods for the synthesis of fluorinated compounds have been intensively studied, recently. Development of practical fluorinating reagents is indispensable for this purpose. Herein, bench-stable electrophilic fluorinating reagents were synthesized as N-fluorobenzenesulfonimide (NFSI) substitutes. Reagents obtained by replacing one of the NFSI sulfonyl groups with an acyl group led to the highly selective monofluorination of silyl enol ethers with suppression of undesired overreaction, that is, difluorination. On the other hand, reagents bearing electron-withdrawing substituents at NFSI benzenesulfonyl groups efficiently facilitated the difluorination of silyl enol ethers under base-free conditions. Thus, both mono- and difluorinated target materials were prepared from the same substrate.

Practical Access to Difluoromethyl Ketones via Straightforward Decarboxylative Difluorination of β-Ketoacids

A facile synthetic approach to a series of difluoromethyl ketones from β-ketoacids has been described. This transformation is achieved through the straightforward decarboxylative difluorination of β-ketoacids in the absence of any catalyst. Furthermore, the resulted difluoromethyl ketones can be easily converted into corresponding difluoromethylated building blocks for pharmaceuticals and materials. (Figure presented.).

Difluorohomologation of ketones

A method for the homologation of ketones with the CF2 fragment is described. The reaction involves silylation, room-temperature difluorocyclopropanation of silyl enol ethers, and selective ring opening of cyclopropanes under acidic conditions. The whole three-step sequence is conveniently performed in a one-pot mode.