70364-29-3

Basic information

• Product Name: 3-[4-(2-ETHOXYCARBONYL-ETHYL)-PHENYL]-PROPIONIC ACID ETHYL ESTER
• Synonyms: 3-[4-(2-ETHOXYCARBONYL-ETHYL)-PHENYL]-PROPIONIC ACID ETHYL ESTER
• CAS NO: 70364-29-3
• Molecular Formula: C₁₆H₂₂O₄
• Molecular Weight: 278.34348
• Mol File: 70364-29-3.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-[4-(2-ETHOXYCARBONYL-ETHYL)-PHENYL]-PROPIONIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[4-(2-ETHOXYCARBONYL-ETHYL)-PHENYL]-PROPIONIC ACID ETHYL ESTER(70364-29-3)
• EPA Substance Registry System: 3-[4-(2-ETHOXYCARBONYL-ETHYL)-PHENYL]-PROPIONIC ACID ETHYL ESTER(70364-29-3)

Safety Data

• Hazardous Substances Data: 70364-29-3(Hazardous Substances Data)

Usage

General Description

3-[4-(2-ethoxycarbonyl-ethyl)-phenyl]-propionic acid ethyl ester is a chemical compound belonging to the class of propionic acid derivatives. It is a synthetic organic compound with the molecular formula C19H22O4. This chemical is commonly used as a non-steroidal anti-inflammatory drug (NSAID) and is known for its analgesic and anti-inflammatory properties. It acts by inhibiting the production of prostaglandins, thereby reducing pain and inflammation in the body. 3-[4-(2-ETHOXYCARBONYL-ETHYL)-PHENYL]-PROPIONIC ACID ETHYL ESTER is often used in the pharmaceutical industry for the formulation of pain relief medications and has potential therapeutic applications in the management of various inflammatory conditions.

Upstream product

• 4251-21-2 3,3'-(1,4-phenylene)dipropanoic acid 
• 23746-57-8 diethyl (2E,2′E)-3,3′-benzene-1,4-diylbis-prop-2-enoate 
• 141-97-9 ethyl acetoacetate 
• 623-25-6 p-Xylylene dichloride 
• 64-17-5 ethanol 
• 106-37-6 1.4-dibromobenzene 
• 140-88-5 ethyl acrylate 
• 3054-95-3 acrylaldehyde diethyl acetal 
• 624-38-4 para-diiodobenzene 
• 623-27-8 terephthalaldehyde, 
• 16323-43-6 1,4-phenylenediacrylic acid 
• 23713-85-1 1,4-phenylenediacrylic acid 
• 17088-28-7 ethyl 3-(4-(2-ethoxycarbonylvinyl)phenyl)propenoate 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 4251-21-2 3,3'-(1,4-phenylene)dipropanoic acid 
• 19417-58-4 [1,4-phenylene]-bis(3-hydroxypropane) 
• 19417-59-5 1,4-bis-(3-bromopropyl)-benzene 
• 85784-82-3 1,4-bis(4-cyanopropyl)benzene 
• 85784-83-4 4-[4-(3-Ethoxycarbonyl-propyl)-phenyl]-butyric acid ethyl ester 
• 78704-75-3 4,4'-p-phenylenebis(valeroyl chloride) 
• 144582-02-5 C₂₆H₃₆N₂ 
• 144582-14-9 4-[4-(3-Carboxy-propyl)-2-nitro-phenyl]-butyric acid 
• 144582-16-1 5-[4-(4-Carboxy-butyl)-2-nitro-phenyl]-pentanoic acid 
• 144582-28-5 C₂₈H₄₀N₂ 
• 144582-13-8 4-[4-(3-Ethoxycarbonyl-propyl)-2-nitro-phenyl]-butyric acid ethyl ester 
• 144582-15-0 5-[4-(4-Ethoxycarbonyl-butyl)-2-nitro-phenyl]-pentanoic acid ethyl ester 
• 144582-12-7 2-{3-[4-(4,4-Dicarboxy-butyl)-phenyl]-propyl}-malonic acid 
• 144582-03-6 1,4-Bis<4-(5-formyl-2,4-dimethylpyrrol-3-yl)butyl>benzene 

Relevant articles and documents

One-Pot, Tandem Wittig Hydrogenation: Formal C(sp3)-C(sp3) Bond Formation with Extensive Scope

A one-pot, tandem Wittig hydrogenation of aldehydes with stabilized ylides is reported, representing a formal C(sp3)-C(sp3) bond construction. The tandem reaction operates under mild conditions, is high yielding, and is broad in scope. Chemoselectivity for olefin reduction is observed, and the methodology is demonstrated in the synthesis of lapatinib analogues and a formal synthesis of (±)-cuspareine. Early insights suggest that the chemoselectivity observed in the reduction step is due to partial poisoning of the catalyst, after step one, thus adding to the power of the one-pot procedure.

EMM-28, A NOVEL SYNTHETIC CRYSTALLINE MATERIAL, ITS PREPARATION AND USE

A novel synthetic crystalline material, EMM-28, can be synthesized in the presence of an organic structure directing agent (Q) selected from one or more of the following dications: EMM-28 may be used in organic compound conversion reactions and sorptive processes.

3-arylpropanoate esters through the palladium-catalyzed reaction of aryl halides with acrolein diethyl acetal

The reaction of aryl halides with acrolein diethyl acetal in the presence of Pd(OAc)2, n-Bu3N, and n-Bu4NCl in DMF at 90°C affords ethyl 3-arylpropanoates. A variety of functional groups are tolerated in the aryl halides, including ether, aldehyde, ketone, ester, nitrile, and nitro groups. ortho-Substituents do not hamper the reaction. 3-Arylpropanoate esters were isolated in good to excellent yields with many neutral, electron-rich and electron-poor aryl iodides and electron-poor aryl bromide. Neutral and electron-rich aryl bromides gave the desired ester in moderate yields.