70381-92-9

Basic information

• Product Name: 3,4-Dihydro-2H-pyrano[3,2-b]pyridine
• Synonyms: 3,4-Dihydro-2H-pyrano[3,2-b]pyridine
• CAS NO: 70381-92-9
• Molecular Formula: C₈H₉NO
• Molecular Weight: 135.16316
• Mol File: 70381-92-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 227.407 °C at 760 mmHg
• Flash Point: 82.684 °C
• Appearance: /
• Density: 1.121 g/cm³
• Storage Temp.: 2-8°C
• PKA: 6.18±0.20(Predicted)
• CAS DataBase Reference: 3,4-Dihydro-2H-pyrano[3,2-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Dihydro-2H-pyrano[3,2-b]pyridine(70381-92-9)
• EPA Substance Registry System: 3,4-Dihydro-2H-pyrano[3,2-b]pyridine(70381-92-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 70381-92-9(Hazardous Substances Data)

Usage

Uses

3,4-Dihydro-2H-pyrano[3,2-b]pyridine is used in an iridium-based photoredox catalytic system for radical conjugate addition of nitrogen heterocycles to alkenes.

Upstream product

• 70381-91-8 2-(3-hydroxypropyl)pyridin-3-ol 
• 139745-90-7 (E)-ethyl 3-(3-(benzyloxy)-2-pyridinyl)propenoate 
• 139745-92-9 ethyl 3-(3-hydroxy-2-pyridinyl)propanoate 
• 14047-53-1 3-hydroxy-2-hydroxymethylpyridine 
• 6059-29-6 3-Benzyloxy-2-(hydroxymethyl)pyridine 
• 94454-57-6 3-(phenylmethoxy)-2-pyridinecarboxaldehyde 
• 109-00-2 3-HYDROXYPYRIDINE 

Downstream Products

• 89479-85-6 2-phenyl-3,4-dihydropyrano<2,3,4-hi>indolizine 
• 1438073-62-1 N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-2H-pyrano[3,2-b]pyridin-5(3H)-yl)propoxy)-7-methoxyquinazolin-4-amine 

Relevant articles and documents

Synthetic method of 3, 4-dihydro-2H-pyran [3, 2-b] pyridine

The invention relates to a synthetic method of 3, 4-dihydro-2H-pyran [3, 2-b] pyridine, and mainly solves the technical problems that according to an existing synthetic method, raw materials are not easily acquired, reaction steps are long, palladium catalysis hydrogenation and debenzylation are achieved by the aid of precious metal palladium, and precious metal palladium is difficultly recycled.The technical scheme includes a synthetic method of the 3, 4-dihydro-2H-pyran [3, 2-b] pyridine. The synthetic method is characterized by including the steps: firstly, adding iodine into sodium carbonate solution with 3-pyridone to obtain a compound 1; secondly, reacting the compound 1 with 1, 3-dibromopropane under presence of alkali compounds, and stirring mixture at the indoor temperature overnight to obtain a compound 2; thirdly, reacting the compound 2 with n-butyllithium in tetrahydrofuran at the lower temperature to obtain a target compound 3, 4 dihydro-2H-pyran [3, 2-b] pyridine. The pyridine is provided with important framework structures of synthetic drugs.

AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE

The present invention relates to the field of medicine. Provided herein are aminoquinazoline derivatives, their salts and pharmaceutical formulations useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. Also provided herein are pharmaceutically acceptable compositions comprising the aminoquinazoline compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.