70415-50-8

Basic information

• Product Name: 6-Chloro-4-hydroxy-2-methyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylic acid methyl ester 1,1-dioxide
• Synonyms: 6-chloro-4-hydroxy-2-methyl-2h-thieno[2,3-e]-1,2-thiazine-3-carboxylic acid methyl ester 1,1-dioxide;6-CHLORO-4-HYDROXY-2-METHYL-3-METHO-XYCARBONYL-2H-THIENO[2,3-E]-1,2-THIAZINE-1,1-DIOXIDE;AKOS 90294;LORNOXICAM INTERMEDIATE;XLT-A5;6-Chloro-4-hydroxy-2-methyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylic acid meth;6-chloro-4-hydroxy-2-methyl-2H-thieno[2,3-e]-1,2-thiazine carboxylic acid methyl ester 1,1-dioxide;6-CHLORO-4-HYDROXY-2-METHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA*6*-THIENO[2,3-E][1,2]THIAZINE-3-CARBOXYLIC ACID METHYL ESTER
• CAS NO: 70415-50-8
• Molecular Formula: C₉H₈ClNO₅S₂
• Molecular Weight: 309.75
• EINECS: 1308068-626-2
• Product Categories: APIs Intermediate;(intermediate of lornoxicam);Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 70415-50-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 198-200°C
• Boiling Point: 482.343 °C at 760 mmHg
• Flash Point: 245.513 °C
• Appearance: /
• Density: 1.728
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.663
• Storage Temp.: Refrigerator
• Solubility: Dichloromethane (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 4.50±1.00(Predicted)
• CAS DataBase Reference: 6-Chloro-4-hydroxy-2-methyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylic acid methyl ester 1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-4-hydroxy-2-methyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylic acid methyl ester 1,1-dioxide(70415-50-8)
• EPA Substance Registry System: 6-Chloro-4-hydroxy-2-methyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylic acid methyl ester 1,1-dioxide(70415-50-8)

Safety Data

• Hazardous Substances Data: 70415-50-8(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Uses

Intermediate in the production of Lornoxicam. An analgesic, anti-inflammatory agent.

InChI:InChI=1/C9H8ClNO5S2/c1-11-6(9(13)16-2)7(12)8-4(18(11,14)15)3-5(10)17-8/h3,12H,1-2H3

Upstream product

• 70374-37-7 methyl 5‐chloro‐3‐(methylsulfamoyl)thiophene‐2‐carboxylate 
• 96-32-2 bromoacetic acid methyl ester 

Downstream Products

• 479482-38-7 6-chlorine-4-hydroxy-2-methyl-N-[2-(5'-methyl)thiazolyl]-2H-thieno-[2,3-e]-1,2-thiazine-3-formamide-1,1-dioxide 
• 67-56-1 methanol 
• 169759-98-2 6-Chloro-N-{4-[5-(4-fluorophenyl)-2-furanyl]-2-thiazolyl}-4-hydroxy-2-methyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide 
• 169759-57-3 6-Chloro-4-hydroxy-2-methyl-N-(4phenyl-2-thiazolyl)-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide 
• 70374-39-9 lornoxicam 

Relevant articles and documents

Method for synthesizing lornoxicam intermediate by one-pot method

The invention belongs to the technical field of drug synthesis, and in particular relates to a method for synthesizing a lornoxicam intermediate by a one-pot method. The method is as follows: using 5-chloro-3-methylsulfonamidethiophene-2-carboxylic acid methyl ester as a raw material, and adding methyl bromoacetate and sodium methoxide for alkylation reaction; adding again the sodium methoxide forcyclization reaction to obtain 6-chloro-4-hydroxy-2-methyl-2H-thieno [2,3-e]-1,2-thiazine-3-carboxylic acid methyl ester-1,1-dioxide. The lornoxicam intermediate is synthesized by the one-pot methodby alkylation and cyclization two-step reaction, use of dangerous reagents such as dimethyl sulfate and sodium hydride can be avoided, no dangerous gas is produced during the reaction, side reactionsare reduced, production environment is improved, production safety is ensured, operation is simplified, and product yield is improved.