70565-02-5Relevant articles and documents
Hydrolysis and hydrazinolysis of isatin-based ald-and ketazines
Ibrahim, Hany S.,Abdelhadi, Soha R.,Abdel-Aziz, Hatem A.
, (2015/05/27)
The hydrolysis of isatin aldazine 4a-d afforded the unexpected 3,3'-(hydrazine-1,2-diylidene)bis(indolin-2-one) (5) and 1,2-di(arylidene)hydrazines 6a-d through dual hydrolysis of 4a-d. A mechanism to explain the formation of 5 and 6a-d was proposed. In addition, the hydrazinolysis of 4a-d yielded 3-hydrazonoindolin-2-one (2) and 1,2-di(arylidene)hydrazines 6a-d instead of hydrazones 17a-d, while hydrazinolysis of isatin ketazine 5 gave the expected 3-hydrazonoindolin-2-one (2). These results indicated the ability of the title compounds for unusual hydrolysis and hydrazinolysis reactions.
Novel coordination complexes of the trivalent ruthenium, rhodium and iridium with hydrazones derived from isatin hydrazide and various aldehydes with spectral and biological characterization
Sharma,Srivastava,Srivastava
, p. 387 - 396 (2007/10/03)
A series of several new ruthenium(III), rhodium(III) and iridium(III) complexes with hydrazones of general formula [M(LH)3]Cl3 were synthesized in order to meet requirements essential for biological properties. Hydrazones were formed by isatin hydrazide and various aldehydes namely anisaldehyde, benzaldehyde, o-chlorobenzaldehyde, p-chlorobenzaldehyde and p-fluorobenzaldehyde. Physicochemical characterization of compounds has been carried out by elemental analyses, spectroscopic (IR, electronic, 1H NMR), thermogravimetric and magnetic studies. These complexes show higher conductance values, supporting their electrolytic nature. All the studies revealed octahedral nature of the complexes with nitrogen and oxygen of azomethine and carbonyl group as binding sites and exhibited monomeric nature of the complexes. Rhodium(III) and iridium(III) complexes were found diamagnetic and show intense absorptions while ruthenium(III) complexes show paramagnetic behaviour. In addition, antifungal and antibacterial studies have been carried out in vitro for investigated compounds against fungus A. niger and F. oxysporium and bacteria E. coli and S. aureus. Most of the metal chelates show higher biocidal activity for the above microorganisms than that of the free ligand.
