70565-01-4Relevant articles and documents
Novel thiomorpholine tethered isatin hydrazones as potential inhibitors of resistant Mycobacterium tuberculosis
Karunanidhi, Sivanandhan,Chandrasekaran, Balakumar,Karpoormath, Rajshekhar,Patel, Harun M.,Kayamba, Francis,Merugu, Srinivas Reddy,Kumar, Vishal,Dhawan, Sanjeev,Kushwaha, Babita,Mahlalela, Mavela Cleopus
, (2021/08/03)
Novel chemotherapeutic agents against multidrug resistant-tuberculosis (MDR-TB) are urgently needed at this juncture to save the life of TB-infected patients. In this work, we have synthesized and characterized novel isatin hydrazones 4(a-o) and their thi
Synthesis, biological activity, and docking study of novel isatin coupled thiazolidin-4-one derivatives as anticonvulsants
Nikalje, Anna P.,Ansari, Altamash,Bari, Sanjay,Ugale, Vinod
, p. 433 - 445 (2015/06/08)
A series of 2-(substituted-phenyl)-3-(2-oxoindolin-3-ylidene)amino)-thiazolidin-4-one derivatives were designed and synthesized under microwave irradiation, using an eco-friendly, efficient, microwave-assisted synthetic protocol that involves cyclocondensation of 3-substituted benzylidine-hydrazono-indolin-2-one 3a-j with thioglycolic acid in dimethyl formamide (DMF) as solvent and anhydrous zinc chloride as a catalyst, keeping in view the structural requirement of the pharmacophore. The intermediate compounds 3a-j were obtained by condensation of the hydrazone of indoline-2,3-dione with aromatic aldehydes. The synthesized derivatives were evaluated for CNS depressant activity and anticonvulsant activity in mice using the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (sc-PTZ) induced seizure tests. All the derivatives showed good CNS depressant activity and showed protection in the MES test, indicative of their ability to inhibit the seizure spread. A histopathological study was performed to evaluate liver toxicity caused by the synthesized compounds. The compounds were nontoxic. A computational study was performed, in which log P values were calculated experimentally. Virtual screening was performed by molecular docking of the designed compounds into the ATP binding sites of the NMDA and AMPA receptors, to predict if these compounds have analogous binding modes.
Novel coordination complexes of the trivalent ruthenium, rhodium and iridium with hydrazones derived from isatin hydrazide and various aldehydes with spectral and biological characterization
Sharma,Srivastava,Srivastava
, p. 387 - 396 (2007/10/03)
A series of several new ruthenium(III), rhodium(III) and iridium(III) complexes with hydrazones of general formula [M(LH)3]Cl3 were synthesized in order to meet requirements essential for biological properties. Hydrazones were formed by isatin hydrazide and various aldehydes namely anisaldehyde, benzaldehyde, o-chlorobenzaldehyde, p-chlorobenzaldehyde and p-fluorobenzaldehyde. Physicochemical characterization of compounds has been carried out by elemental analyses, spectroscopic (IR, electronic, 1H NMR), thermogravimetric and magnetic studies. These complexes show higher conductance values, supporting their electrolytic nature. All the studies revealed octahedral nature of the complexes with nitrogen and oxygen of azomethine and carbonyl group as binding sites and exhibited monomeric nature of the complexes. Rhodium(III) and iridium(III) complexes were found diamagnetic and show intense absorptions while ruthenium(III) complexes show paramagnetic behaviour. In addition, antifungal and antibacterial studies have been carried out in vitro for investigated compounds against fungus A. niger and F. oxysporium and bacteria E. coli and S. aureus. Most of the metal chelates show higher biocidal activity for the above microorganisms than that of the free ligand.
