70590-43-1

Basic information

• Product Name: 6(5H)-Benzothiazolone, 4,7-dihydro-
• Synonyms: 6(5H)-Benzothiazolone, 4,7-dihydro-;4,5-dihydrobenzo[d]thiazol-6(7H)-one;4,5,6,7-Tetrahydro-1,3-benzothiazol-6-one;4,5,6,7-tetrahydrobenzothiazol-6-one;4,7-Dihydro-1,3-benzothiazol-6(5H)-one
• CAS NO: 70590-43-1
• Molecular Formula: C7H7NOS
• Molecular Weight: 153.2
• Mol File: 70590-43-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6(5H)-Benzothiazolone, 4,7-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 6(5H)-Benzothiazolone, 4,7-dihydro-(70590-43-1)
• EPA Substance Registry System: 6(5H)-Benzothiazolone, 4,7-dihydro-(70590-43-1)

Safety Data

• Hazardous Substances Data: 70590-43-1(Hazardous Substances Data)

Usage

General Description

6(5H)-Benzothiazolone, 4,7-dihydro- is a chemical compound with the molecular formula C8H7NOS. It is a heterocyclic compound that consists of a benzene ring fused to a thiazole ring. This chemical is commonly used as a building block in organic synthesis and can be found in certain pharmaceutical drugs and agrochemicals. It is also used as an intermediate in the production of dyes and pigments. 6(5H)-Benzothiazolone, 4,7-dihydro- has potential industrial applications and is subject to various regulatory and safety considerations due to its use in manufacturing processes.

Upstream product

• 70590-42-0 oxo-6 ethoxycarbonyl-7 tetrahydro-4,5,6,7 benzothiazole 
• 159015-43-7 6-(ethylenedioxy)-4,5,6,7-tetrahydrobenzothiazole 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 54621-20-4 4-(1,4-dioxaspiro<4.5>dec-7-en-8-yl)morpholine 
• 57440-57-0 1-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)pyrrolidine 
• 159015-34-6 2-chloro-6-(ethylenedioxy)-4,5,6,7-tetrahydrobenzothiazole 
• 159015-33-5 2-amino-6-(ethylenedioxy)-4,5,6,7-tetrahydrobenzothiazole 
• 6317-49-3 4-oxopimelate 
• 59742-68-6 diethyl 3-bromo-4-oxoheptanedioate 

Downstream Products

• 70590-66-8 4,5,6,7-tetrahydro-benzothiazol-6-ylamine 
• 70590-58-8 Etrabamine 

Relevant articles and documents

Synthesis of the thiazolone analogue of the acetylcholinesterase inhibitor, huperzine A

The preparation of an analogue 3a of the acetylcholinesterase inhibitor, huperzine A (1), is described in which the pyridinone moiety of the natural product is replaced with a thiazolone moiety. The synthesis started from cyclohexane-1,4-dione monoethylene ketal (7) by first annulating the thiazole ring using the Gewald protocol (→8) and then constructing the bicyclo[3.3.1]nonane substructure using our previously described Michael addition/aldol condensation methodology. The central problem was the protection of the thiazolone carbonyl group; only the 2-unsubstituted thiazole survived the reaction conditions of the first half of the synthesis. Refunctionalization was later effected by lithiation and subsequent chlorination with hexachloroethane (30→31). Compound 3a was ineffective in the acetylcholinesterase inhibition assay in concentrations up to 14 μM.

New benzo [d] thiazole derivatives, process for their preparation and their therapeutic applications

This invention relates to compounds having the general formula: STR1 and their pharmaceutically acceptable acid addition salts having the formula: STR2 in which: R represents hydrogen or a C1-4 alkyl radical, R' represents hydrogen or a C1-4 alkyl radical, m is 0, 1, 2 or 3, n is 3, 2, 1 or 0, the sum m+n being always equal to 3, and X- represents an anion formed by a pharmaceutically acceptable acid. Said compounds are typically useful as analgesic agents and as stimulants of the sympathetic nervous system, and also as central and peripheral vasoregulator agents.