70590-66-8

Basic information

• Product Name: 6-Benzothiazolamine, 4,5,6,7-tetrahydro-
• Synonyms: 6-Benzothiazolamine, 4,5,6,7-tetrahydro-;4,5,6,7-Tetrahydrobenzo[d]thiazol-6-aMine
• CAS NO: 70590-66-8
• Molecular Formula: C7H10N2S
• Molecular Weight: 154.23
• Mol File: 70590-66-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 286.247°C at 760 mmHg
• Flash Point: 126.918°C
• Appearance: /
• Density: 1.219g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.596
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-Benzothiazolamine, 4,5,6,7-tetrahydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Benzothiazolamine, 4,5,6,7-tetrahydro-(70590-66-8)
• EPA Substance Registry System: 6-Benzothiazolamine, 4,5,6,7-tetrahydro-(70590-66-8)

Safety Data

• Hazardous Substances Data: 70590-66-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H10N2S/c8-5-1-2-6-7(3-5)10-4-9-6/h4-5H,1-3,8H2

Upstream product

• 70590-43-1 4,7-dihydrobenzothiazol-6(5H)-one 
• 6317-49-3 4-oxopimelate 
• 59742-68-6 diethyl 3-bromo-4-oxoheptanedioate 
• 70590-41-9 ethoxycarbonylmethyl-5 (ethoxycarbonyl-2 ethyl) 4 thiazole 
• 70590-42-0 oxo-6 ethoxycarbonyl-7 tetrahydro-4,5,6,7 benzothiazole 
• 106006-81-9 (+/-)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole dihydrobromide 

Relevant articles and documents

MEDICAMENTS

A compound of the following formula is described (I), wherein X, Y, R1 and R are as defined in the text and wherein the compounds are intended for use in treating medical conditions characterized by an imbalance in dopamine receptor activity.

Synthesis of aminoderivatives of 4,5,6,7-tetrahydro-benzothiazole. I. 4,5,6- and 7-amino and N-methyl amino derivatives with central dopaminergic activity

4-Oxo and 6-oxo-4,5,6,7-tetrahydro-benzothiazoles were prepared from diester derivatives of thiazole through Dieckmann cyclisation. The 7-oxo compound was synthesized by formation of a thiazole ring on 2-bromo-1,3-cyclohexanedione. The ketones were tranformed into amines and N-methylamines by reductive amination. The 5-amino derivatives were obtained by Hofmann reaction of the corresponding amides. The amines and N-methylamines in the 6-position have central dopaminergic properties. Their isomers in the 4, 5 or 7 positions are inactive.