70650-50-9Relevant articles and documents
Alkene Difunctionalization Triggered by a Stabilized Allenyl Radical: Concomitant Installation of Two Unsaturated C?C Bonds
Wei, Yunlong,Wu, Xinxin,Zhang, Hong,Zhu, Chen
, p. 20215 - 20219 (2021)
Radical-mediated difunctionalization of alkenes provides a promising approach to introduce one alkenyl or alkynyl group to target compounds. However, simultaneous installation of two unsaturated C?C bonds via alkene difunctionalization remains elusive, at
Synthesis of α-Acyloxy-α′-hydroxy Ketones via Cyclic Carbonate Intermediates Generated from Tertiary Bromopropargylic Alcohols and Cs2CO3
Shemyakina, Olesya A.,Volostnykh, Ol'ga G.,Stepanov, Anton V.,Ushakov, Igor' A.
supporting information, p. 7117 - 7121 (2019/11/16)
A facile approach towards α-acyloxy-α′-hydroxy ketones by reaction of readily available tertiary bromopropargylic alcohols and carboxylic acids in system Cs2CO3/H2O/DMF (50–55 °C, 4 h) was developed. Key intermediates of this synthesis are cyclic carbonates generated in situ from bromopropargylic alcohols and Cs2CO3 which have been utilized as both reagent and base promoter.
Palladium-catalyzed bromoalkynylation of C-C double bonds: Ring-structure-dependent synthesis of 7-alkynyl norbornanes and cyclobutenyl halides
Li, Yibiao,Liu, Xiaohang,Jiang, Huanfeng,Liu, Bifu,Chen, Zhengwang,Zhou, Peng
supporting information; experimental part, p. 6341 - 6345 (2011/09/13)
Strain versus flexibility: The palladium-catalyzed reaction of haloalkynes with norbornene derivatives leads to 7-alkynyl norbornane products (see scheme). Key to the success of this reaction is the formation of a "bridging" palladium species, which can rearrange to result in a C-7 functionalization. The ring-structure-dependent [2+2] cycloaddition of haloalkynes with cyclooctene has been achieved in moderate to good yields under similar conditions. Copyright
