127-66-2 Usage
Description
2-Phenyl-3-butyn-2-ol is an organic compound characterized by its white, semi-transparent crystalline appearance. It is known for its unique chemical properties that make it a versatile building block in various synthetic applications.
Uses
Used in Chemical Synthesis:
2-Phenyl-3-butyn-2-ol is used as a key intermediate in the synthesis of various organic compounds. Its reactivity and structural features allow it to be employed in multiple chemical reactions, leading to the formation of a wide range of products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Phenyl-3-butyn-2-ol is used as a building block for the development of new drugs. Its unique structure and reactivity make it a valuable component in the synthesis of various medicinal compounds.
Used in Material Science:
2-Phenyl-3-butyn-2-ol is also utilized in the field of material science, where it contributes to the development of novel materials with specific properties. Its incorporation into different chemical structures can lead to materials with enhanced performance characteristics.
Specific Applications:
1. Copper (II)-Promoted Cycloaddition to Azides:
2-Phenyl-3-butyn-2-ol is used in the copper (II)-promoted cycloaddition to azides, leading to the formation of triazoles. This reaction is significant in the synthesis of various organic compounds, including those with potential applications in pharmaceuticals and materials science.
2. Preparation of (3-Methyl-5-isoxazolyl)(Phenyl)-Methanol and 1-(3-Methyl-5-isoxazolyl)-1-Phenyl-1-Ethanol:
The compound is employed in the preparation of (3-methyl-5-isoxazolyl)(phenyl)-methanol and 1-(3-methyl-5-isoxazolyl)-1-phenyl-1-ethanol, which are important intermediates in the synthesis of various organic molecules.
3. α-Methylene Cyclic Carbonates:
2-Phenyl-3-butyn-2-ol is used in the synthesis of α-methylene cyclic carbonates via a reaction with CO2, catalyzed by transition metal salts in ionic liquids. These carbonates have potential applications in the development of polymers and other materials.
4. Aqueous Copper (II)-Promoted Cycloaddition to Azides:
The compound is also used in an aqueous copper (II)-promoted cycloaddition to azides, which is another method to synthesize triazoles. This reaction is valuable for the development of new organic compounds with potential applications in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 127-66-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 7 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 127-66:
(5*1)+(4*2)+(3*7)+(2*6)+(1*6)=52
52 % 10 = 2
So 127-66-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H10O/c1-3-10(2,11)9-7-5-4-6-8-9/h1,4-8,11H,2H3/t10-/m1/s1
127-66-2Relevant articles and documents
Collision-induced fragmentation of ionized 3-phenyl-1-butyn-3-ol mediated by an intermediate proton-bound complex [3]
She,Tu,Song,Liu
, p. 1191 - 1192 (1996)
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BTK Inhibitors and uses thereof
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, (2020/05/02)
The invention discloses a bruton's tyrosine kinase (BTK) inhibitor and use thereof. Specifically, the invention provides heteroaromatic compounds or stereoisomers, geometrical isomers, tautomers, racemates, nitrogen oxides, hydrates, solvates, metabolites and pharmaceutically acceptable salts or prodrugs thereof, and pharmaceutical compositions containing the heteroaromatic compounds; the invention also discloses use of the heteroaromatic compounds or the pharmaceutical compositions containing the heteroaromatic compounds in preparation of medicines; the medicines can be used for treating autoimmune diseases, inflammatory diseases or proliferative diseases.
Kinetic Resolution of Tertiary Propargylic Alcohols by Enantioselective Cu?H-Catalyzed Si?O Coupling
Seliger, Jan,Dong, Xichang,Oestreich, Martin
supporting information, p. 1970 - 1974 (2019/01/29)
A broad range of tertiary propargylic alcohols were kinetically resolved by catalyst-controlled enantioselective silylation. This non-enzymatic kinetic resolution is catalyzed by a Cu?H species and makes use of the commercially available precatalyst MesCu/(R,R)-Ph-BPE and a simple hydrosilane as the resolving reagent. Both alkyl,aryl- as well as dialkyl-substituted propargylic alcohols participate, and especially high selectivity factors are achieved when the alkyne terminus carries a TIPS group, which also enables facile post-functionalization in this position (s up to 207).
Cycloisomerization of Conjugated Allenones into Furans under Mild Conditions Catalyzed by Ligandless Au Nanoparticles
Zorba, Leandros,Kidonakis, Marios,Saridakis, Iakovos,Stratakis, Manolis
supporting information, p. 5552 - 5555 (2019/08/01)
Au nanoparticles supported on TiO2 (1 mol %) catalyze the quantitative cycloisomerization of conjugated allenones into furans under very mild conditions. The reaction rate is accelerated by adding acetic acid (1 equiv), but the acid does not participate in the protodeauration step as in the corresponding Au(III)-catalyzed transformation. The process is purely heterogeneous, allowing thus the recycling and reuse of the catalyst effectively in several runs.
