2404-87-7Relevant articles and documents
Suzuki-Miyaura coupling under air in water promoted by polymer supported palladium nanoparticles
Dell'Anna, Maria Michela,Mali, Matilda,Mastrorilli, Piero,Rizzuti, Antonino,Ponzoni, Chiara,Leonelli, Cristina
, p. 186 - 194 (2013)
Suzuki couplings of aryl bromides were efficiently performed by a polymer supported palladium catalyst under air in water at 100°C without additives. In the case of activated aryl chlorides the reactions proceeded smoothly in the presence of a suitable phase transfer agent. The catalyst was active and recyclable for at least five times. Atomic absorption analyses revealed that the metal content in the polymeric support did not significantly decrease with the cycles while inductively coupled plasma analyses revealed that the palladium amount both in the mother liquors and in the organic products after reactions was lower than 500 ppb. The activity of the mother liquors has been investigated in detail. A transmission electron microscopy study of the supported catalyst before, during and after duty is also described.
Structure and Internal Rotation in 3-Phenylthiophene Using NMR Spectra of Liquid-Crystalline Solutions
Chidichimo, Giuseppe,Liguori, Angelo,Longeri, Marcello,Veracini, Carlo Alberto
, p. 438 - 445 (1983)
The NMR spectra of 3-phenylthiophene as solute in liquid-crystal solvents were analyzed and the direct couplings constants, Dij obtained were used to test different models of the potential energy function V(φ) for intramolecular rotation of the phenyl and thiophene units.The data are consistent with a V(φ) having a minimum at about 24 deg.The LCNMR technique is highly discriminant among different models of V(φ) provided that enough Dij couplings are available.Ab initio calculations are also reported.
A C3v-symmetric triphosphine ligand derived from trindane skeleton: synthesis, inclusion of C60, and catalytic activity of its Pd complex
Lim, Dong Seob,Sahoo, Suban K.,Cho, Chan Sik,Kim, Yang,Choi, Heung-Jin
, p. 5665 - 5669 (2015)
With the aim to design a multidentate C3v-symmetric trindane-based trisphosphine ligand 3 for Suzuki-Miyaura cross-coupling of 3-bromothiophene with phenylboronic acid, we observed the ability of this ligand to form an inclusion complex with buckyball C60. Along with its catalytic activity, the pyramidal inversion at phosphorous atoms of 3 and the formation of 3@C60 were investigated by 1H NMR, 31P{1H} NMR and DFT methods.
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Davies et al.
, p. 795 (1976)
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Organocatalytic synthesis of (Het)biaryl scaffoldsviaphotoinduced intra/intermolecular C(sp2)-H arylation by 2-pyridone derivatives
Das, Tapas Kumar,Kundu, Mrinalkanti,Mondal, Biswajit,Ghosh, Prasanjit,Das, Sajal
, p. 208 - 218 (2021/12/29)
A uniqueN,O-bidentate ligand 6-oxo-1,6-dihydro-pyridone-2-carboxylic acid dimethylamide (L1) catalyzed direct C(sp2)-H (intra/intermolecular) arylation of unactivated arenes has been developed to expedite access to (Het)biaryl scaffolds under UV-irradiation at room temperature. The protocol tolerated diverse functional groups and substitution patterns, affording the target products in moderate to excellent yields. Mechanistic investigations were also carried out to better understand the reaction pathway. Furthermore, the synthetic applicability of this unified approach has been showcasedviathe construction of biologically relevant 4-quinolone, tricyclic lactam and sultam derivatives.
Cap-dependent endonuclease inhibitors
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Paragraph 0330; 0343-0346, (2021/11/10)
The present invention provides a compound of formula (I) for inhibiting influenza virus replication. A pharmaceutically acceptable salt, metabolite, or prodrug thereof. The compounds can be used for preparing medicaments for treating influenza. The invention further discloses a method and for preparing the same, and a composition comprising the compound and a pharmaceutically acceptable carrier.
2-Phosphinoimidazole Ligands: N-H NHC or P-N Coordination Complexes in Palladium-Catalyzed Suzuki-Miyaura Reactions of Aryl Chlorides
Martinez, Erin E.,Larson, Alexandra J. S.,Fuller, Sydney K.,Petersen, Kathryn M.,Smith, Stacey J.,Michaelis, David J.
supporting information, p. 1560 - 1564 (2021/05/29)
We report the synthesis of two palladium 2-(dialkylphosphino)imidazole complexes and demonstrate their activity as catalysts for Suzuki-Miyaura reactions with (hetero)aryl chlorides at room temperature. Our mechanistic studies demonstrate that these palladium complexes exist as an equilibrium mixture between the P-N coordinated and N-H NHC forms of ligand. Our studies suggest that the N-H NHC form may be important for high catalytic activity in Suzuki-Miyaura reactions with aryl chlorides. These reactions proceed at or near room temperature in good to excellent yields. Heteroaryl chlorides are also reactive at lower catalyst loadings.
