70650-90-7

Basic information

• Product Name: 3,5-bis(3-chlorophenyl)-1,2,4-thiadiazole
• CAS NO: 70650-90-7
• Molecular Formula: C₁₄H₈Cl₂N₂S
• Molecular Weight: 307.1977
• Mol File: 70650-90-7.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 470.2°C at 760 mmHg
• Flash Point: 238.1°C
• Density: 1.397g/cm³
• Vapor Pressure: 1.46E-08mmHg at 25°C
• Refractive Index: 1.646
• CAS DataBase Reference: 3,5-bis(3-chlorophenyl)-1,2,4-thiadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-bis(3-chlorophenyl)-1,2,4-thiadiazole(70650-90-7)
• EPA Substance Registry System: 3,5-bis(3-chlorophenyl)-1,2,4-thiadiazole(70650-90-7)

Safety Data

• Hazardous Substances Data: 70650-90-7(Hazardous Substances Data)

Upstream product

• 2548-79-0 3-chlorothiobenzamide 
• 766-84-7 3-chloro-benzonitrile 
• 57626-33-2 2-bromo-1-phenyl-1,3-butanedione 

Relevant articles and documents

Visible-light promoted serendipitous synthesis of 3,5-diaryl-1,2,4-thiadiazoles via oxidative dimerization of thiobenzamides

In the present manuscript, we report serendipitous synthesis of 3,5-diaryl-1,2,4-thiadiazoles with the aid of a household compact fluorescent lamp (CFL). In presence of α-bromo-β-diketone, thiobenzamides undergo oxidative dimerization to generate corresponding 3,5-diaryl-1,2,4-thiadiazoles in excellent yields in just 5 min instead of expected 2-aryl-4-methyl-5-acylthiazoles. Inhibition of the reaction by free radical scavenger (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) indicates that the dimerization takes place through a free radical process. The synthetic value of the developed protocol was established by synthesizing over eleven diverse 1,2,4-thiadiazoles in a shorter duration with exceptionally high purity and simple work-up procedure under environment benign additive-free conditions.

Expedient Synthesis of 1,2,4-Thiadiazoles from Primary Thioamides Using Calcium Hypochlorite in Dichlomethane

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Regioselective C-C cross-coupling of 1,2,4-thiadiazoles with maleimides through iridium-catalyzed C-H activation

A regioselective C-C cross-coupling of 1,2,4-thiadiazoles with maleimides through iridium catalysis was developed. This transformation tactically linked the 1,2,4-thiadiazoles and succinimides together, and the novel molecules formed may have potential biological activity.