70744-03-5

Basic information

• Product Name: 2(1H)-Quinolinone, 3-amino-4-hydroxy-1-methyl-
• Synonyms: 2(1H)-Quinolinone, 3-amino-4-hydroxy-1-methyl-
• CAS NO: 70744-03-5
• Molecular Formula: C₁₀H₁₀N₂O₂
• Molecular Weight: 190.2
• Mol File: 70744-03-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 322-327 °C (decomp)(Solv: ethanol (64-17-5))
• Boiling Point: 320.0±42.0 °C(Predicted)
• Appearance: /
• Density: 1.381±0.06 g/cm3(Predicted)
• PKA: 5.80±0.20(Predicted)
• CAS DataBase Reference: 2(1H)-Quinolinone, 3-amino-4-hydroxy-1-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Quinolinone, 3-amino-4-hydroxy-1-methyl-(70744-03-5)
• EPA Substance Registry System: 2(1H)-Quinolinone, 3-amino-4-hydroxy-1-methyl-(70744-03-5)

Safety Data

• Hazardous Substances Data: 70744-03-5(Hazardous Substances Data)

Usage

Chemical structure

2(1H)-Quinolinone with an amino group at the 3 position, a hydroxy group at the 4 position, and a methyl group at the 1 position.

Potential biological and pharmacological properties

The compound has been studied for its potential use in the treatment of various diseases, including cancer and neurodegenerative disorders, due to its ability to modulate various cellular pathways and processes.

Antioxidant and anti-inflammatory properties

The compound has been investigated for its antioxidant and anti-inflammatory properties, which could have applications in the development of novel medications.

Upstream product

• 36949-55-0 4-hydroxy-1-methyl-3-nitro-2-(1H)quinolinone 
• 125552-72-9 C₁₅H₁₂N₂O₂ 
• 35472-56-1 N-methyl-anthranilic acid ethyl ester 
• 99105-33-6 N-chloroacetyl-N-methyl-anthranilic acid ethyl ester 
• 1677-46-9 4-hydroxy-1-methyl-2(1H)-quinolone 

Downstream Products

• 41878-54-0 3,4-Dihydroxy-1-methyl-chinolin-2(1H)-on 
• 1309361-97-4 C₂₅H₂₂N₂O₆S 
• 1309361-98-5 C₂₇H₂₆N₂O₈S 
• 1309361-99-6 C₂₄H₁₉FN₂O₅S 
• 1309362-00-2 C₂₂H₁₈N₂O₅S₂ 
• 1309362-01-3 C₂₆H₂₁N₃O₅S 
• 1309362-02-4 C₂₁H₂₂N₂O₅S 
• 1309362-04-6 C₂₉H₂₈N₂O₆S 
• 1309362-05-7 C₂₉H₂₆N₂O₆S 
• 1309362-07-9 C₂₄H₂₂N₂O₈S₂ 
• 1309362-11-5 C₁₇H₁₃FN₂O₃ 
• 1309362-10-4 C₂₀H₂₀N₂O₆ 
• 1375313-74-8 3-(11-(1H-benzo[d][1,2,3]triazol-1-yloxy)undecanamido)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl 4-methylbenzenesulfonate 

Relevant articles and documents

Synthesis and antikinetoplastid activities of 3-substituted quinolinones derivatives

A new family of quinolinone derivatives has been synthesized and evaluated for their antikinetoplastid activities against Leishmania donovani and Trypanosoma brucei brucei. Results from these structure-activity relationship studies enabled identification of compounds 3a and 4g as the most active compounds against L. donovani promastigotes and amastigotes parasites (IC 50 values in a range of 2-11 μM). Additionally, compound 3b has emerged from this study as the most active compound in the series against T. b. brucei with a MEC value of 12 μM. These three compounds are worth of further in vivo evaluation.

4-hydroxy-2-quinolones. 31. 3-amino-1R-2-oxo-4-hydroxyquinolines and their acyl derivatives

An alternative method has been developed for preparing and studying the antioxidant activity of 3-acylamino-2-oxo-4-hydroxyquinolones. Results are presented from an investigation of the antithyroid and antimicrobial action of the intermediate 2-oxo-3-(1-pyridinio)quinolin-4-olates and the 3-amino-2-oxo-4-hydroxyquinolines. 1997 Plenum Publishing Corporation.

A synthesis of 3 amino 4 hydroxyquinolin 2(1H) one derivatives via oxazolo[4,5 c]quinolin 4(5H) ones

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