709668-57-5Relevant articles and documents
4-(tert-Butyldimethylsilyloxy)benzylidene acetal: A novel benzylidene-type protecting group for 1,2-diols
Kaburagi, Yosuke,Osajima, Hiroyuki,Shimada, Kousei,Tokuyama, Hidetoshi,Fukuyama, Tohru
, p. 3817 - 3821 (2007/10/03)
A novel 1,2-diol-protecting group, p-silyloxybenzylidene group, has been developed. In addition to the stepwise deprotection conditions including desilylation and the subsequent acidic hydrolysis of the p-hydroxybenzylidene group in AcOH-THF-H2O, we have established the one-pot deprotection under basic conditions [K2CO3 (5equiv), NH 2OH·HCl (5equiv), and CsF (1equiv) in MeOH-H2O].