71019-06-2

Basic information

• Product Name: 1(2H)-Naphthalenone, 2-fluoro-3,4-dihydro-
• Synonyms: 1(2H)-Naphthalenone, 2-fluoro-3,4-dihydro-
• CAS NO: 71019-06-2
• Molecular Formula: C₁₀H₉FO
• Molecular Weight: 164.18
• Mol File: 71019-06-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 38-39.5 °C
• Boiling Point: 253.9±29.0 °C(Predicted)
• Appearance: /
• Density: 1.17±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 1(2H)-Naphthalenone, 2-fluoro-3,4-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1(2H)-Naphthalenone, 2-fluoro-3,4-dihydro-(71019-06-2)
• EPA Substance Registry System: 1(2H)-Naphthalenone, 2-fluoro-3,4-dihydro-(71019-06-2)

Safety Data

• Hazardous Substances Data: 71019-06-2(Hazardous Substances Data)

Usage

Description

1(2H)-Naphthalenone, 2-fluoro-3,4-dihydrois a chemical compound with the molecular formula C10H9FO. It belongs to the class of naphthalenones, which are derivatives of naphthalene. This specific compound is characterized by the presence of a fluorine atom at the 2-position and a dihydro-1(2H)-naphthalenone structure. Its chemical structure and properties make it useful in various chemical and pharmaceutical applications, including as an intermediate in the synthesis of other compounds.

Uses

Used in Chemical Synthesis:
1(2H)-Naphthalenone, 2-fluoro-3,4-dihydrois used as an intermediate in the chemical synthesis of other compounds. Its unique structure and properties allow for the creation of new materials and pharmaceutical drugs.
Used in Pharmaceutical Applications:
In the pharmaceutical industry, 1(2H)-Naphthalenone, 2-fluoro-3,4-dihydrois used as a building block for the development of new drugs. Its chemical structure can be modified and combined with other molecules to create potential therapeutic agents.
Used in Material Development:
1(2H)-Naphthalenone, 2-fluoro-3,4-dihydrois also utilized in the development of new materials due to its unique chemical properties. It can be incorporated into various formulations to enhance their performance or introduce new functionalities.

Upstream product

• 19455-84-6 3,4-dihydronaphthalen-1-yl acetate 
• 84716-82-5 4-methoxy-1,2-dihydronaphthalene 
• 146514-98-9 tert-butyl hypofluorite 
• 38858-72-9 1-trimethylsiloxy-3,4-dihydronaphthalene 
• 928768-24-5 (2-fluoro-3,4-dihydronaphthalen-1-yloxy)trimethylsilane 
• 106-38-7 para-bromotoluene 
• 624-31-7 4-tolyl iodide 
• 108-86-1 bromobenzene 
• 99-90-1 para-bromoacetophenone 
• 1221794-77-9 tri-n-propyl(2-fluoro-3,4-dihydronaphthalen-1-yloxy)silane 

Downstream Products

• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 247913-25-3 2-fluoro-2-(3-methyl-benzyl)-3,4-dihydro-2H-naphthalen-1-one 
• 247913-11-7 (S)-2-benzyl-2-fluoro-3,4-dihydro-2H-naphthalen-1-one 
• 247913-26-4 (S)-2-fluoro-2-(4-methylbenzyl)-3,4-dihydro-2H-naphthalen-1-one 
• 247913-27-5 2-(4-bromo-benzyl)-2-fluoro-3,4-dihydro-2H-naphthalen-1-one 
• 247913-24-2 2-fluoro-2-(2-methyl-benzyl)-3,4-dihydro-2H-naphthalen-1-one 
• 1155878-26-4 2-fluoro-2-phenyl-3,4-dihydronaphthalene-1(2H)-one 
• 1155878-40-2 2-fluoro-2-(4-methoxyphenyl)-3,4-dihydronaphthalene-1(2H)-one 
• 1155878-27-5 2-fluoro-2-(4-methylphenyl)-3,4-dihydronaphthalene-1(2H)-one 
• 1155878-28-6 methyl 3-(1,2,3,4-tetrahydro-2-fluoro-1-oxo-2-naphthalenyl)benzoate 
• 1155878-29-7 4-(1,2,3,4-tetrahydro-2-fluoro-1-oxo-2-naphthalenyl)benzonitrile 
• 1155878-32-2 2-fluoro-2-(4-(trifluoromethyl)phenyl)-3,4-dihydronaphthalen-1(2H)-one 
• 1290086-41-7 N-((S)-((R)-2-fluoro-1-oxol-1,2,3,4-tetrahydronaphthalen-2-yl)(4-methoxyphenyl)methyl)methanesulfonamide 

Relevant articles and documents

The Electrophilic Fluorination of Enol Esters Using SelectFluor: A Polar Two-Electron Process

The reaction of enol esters with SelectFluor is facile and leads to the corresponding α-fluoroketones under mild conditions and, as a result, this route is commonly employed for the synthesis of medicinally important compounds such as fluorinated steroids. However, despite the use of this methodology in synthesis, the mechanism of this reaction and the influence of structure on reactivity are unclear. A rigorous mechanistic study of the fluorination of these substrates is presented, informed primarily by detailed and robust kinetic experiments. The results of this study implicate a polar two-electron process via an oxygen-stabilised carbenium species, rather than a single-electron process involving radical intermediates. The structure–reactivity relationships revealed here will assist synthetic chemists in deploying this type of methodology in the syntheses of α-fluoroketones.

Impact of silyl enol ether stability on palladium-catalyzed arylations

The effect of stability on arylation of silyl enol ethers as dictated by the presence of bulky silyl groups was elucidated through experiment and calculation. With the enhancement of stability of the silyl enol ethers, especially of acyclic ethers, the ef

Reaction of silyl enol ethers with xenon difluoride in MeCN: Evidence for a nonclassical radical cation intermediate

(matrix presented). The reactions of xenon difluoride in MeCN solution in Pyrex flasks with a series of TMS enol ethers have been investigated. The types of products formed are dependent on the structures of individual enol ethers, but under these conditions all products are consistent with a mechanism involving single electron transfer to un-ionized XeF2 giving a radical cation and subsequent formation of an α-fluoroketone, together with some ketone formation. The results suggest that if the radical cation is particularly stable, fluorodesilylation leads to radical formation, and solvent-derived products are then observed. Using other solvents, such as CFCl3 and C6F6, much more complex mixtures of products are obtained, and this is attributed to a different mode of reaction of xenon difluoride involving ionization to FXe+.