7115-18-6Relevant articles and documents
Salicylic Acid-Catalyzed Arylation of Enol Acetates with Anilines
Felipe-Blanco, Diego,Gonzalez-Gomez, Jose C.
supporting information, p. 2773 - 2778 (2018/07/29)
α-Aryl ketones are both structure moieties commonly found in bioactive compounds and versatile synthetic intermediates for the preparation of drug-like molecules. An operationally simple and scalable protocol has been developed to prepare α-aryl ketones from readily available aromatic amines and enol acetates (or silyl enol ethers). This metal-free methodology features the use of salicylic acid as a convenient catalyst to promote the formation of aryl radicals from in-situ generated aryl diazonium salts, without demanding thermal or photochemical activation. The mild reaction conditions used are compatible with anilines substituted with diverse functionalities. Structural elaboration of some prepared α-aryl ketones was accomplished to illustrate their usefulness as building blocks. (Figure presented.).
Continuous-flow synthesis of trimethylsilylphenyl perfluorosulfonate benzyne precursors
Michel, Boris,Greaney, Michael F.
supporting information, p. 2684 - 2687 (2014/06/09)
2-(Trimethylsilyl)phenyl perfluorosulfonated aryne precursors may now be accessed using flow chemistry, enabling the fast preparation of pure compounds with no requirement for low temperature lithiation or column chromatography. The process has been adapted to novel nonaflate precursors, utilizing the cheaper and more user-friendly nonaflyl fluoride reagent. The resultant nonaflates are shown to successfully participate in a range of aryne reaction classes.
Aqueous organotin chemistry: Tin hydride mediated dehalogenation of organohalides and a novel organotin mediated nucleophilic substitution on 2- iodobenzoates in water
Sarma, Koushik Das,Maitra, Uday
, p. 4965 - 4976 (2007/10/03)
This paper describes the dehalogenation of water soluble and water insoluble organohalides in water by tri-n-butyltin hydride (TBTH), preformed TBTH and triphenyltin hydride (TPTH) in water. TBTH in the presence of a radical trap, and Ph4Sn were also found to effect nucleophilic substitution of 2-iodobenzoates in the presence of various nucleophiles.