715-91-3Relevant articles and documents
Synthetic strategies to 9-substituted 8-oxoadenines
Siah, Huey-San Melanie,Gundersen, Lise-Lotte
supporting information, p. 1469 - 1476 (2013/05/09)
Three synthetic routes to 9-substituted 8-oxoadenines have been studied: bromination of adenine followed by N-9-alkylation/arylation and finally hydrolysis; bromination of adenine, hydrolysis, and N-functionalization as the last step; and N-9-alkylation of adenine, halogenation, and finally hydrolysis. As long as the N-9-functional group is compatible with conditions required for introduction of the halogen, the latter strategy was the most efficient. Also, a strategy starting from 5-amino-4,6-dichloropyrimidine was found to be a very good alternative for synthesis of 9-substituted 8-oxoadenines. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications1 to view the free supplemental file. Copyright Taylor & Francis Group, LLC.
Synthesis and antimicrobial evaluation of some new substituted purine derivatives
Tuncbilek, Meral,Ates-Alagoez, Zeynep,Altanlar, Nurten,Karayel, Arzu,Oezbey, Sueheyla
experimental part, p. 1693 - 1700 (2009/09/05)
A series of 8,9-disubstituted adenines (4, 5, 8), 6-substituted aminopurines (10-13) and 9-(p-fluorobenzyl/cyclopentyl)-6-substituted aminopurines (16, 17, 19-30) have been prepared and the antimicrobial activities of these compounds against Staphylococcu
An efficient Mitsunobu coupling to adenine-derived carbocyclic nucleosides
Yin, Xue-qiang,Li, Wei-kuan,Schneller, Stewart W.
, p. 9187 - 9189 (2007/10/03)
Adenine is a poor substrate for the Mitsunobu process to carbocyclic nucleosides. However, N-6 amino bis-Boc-protected adenine is reported herein to undergo an efficient coupling under these conditions as a result of its increased solubility and the reduc
