716-79-0Relevant articles and documents
Effect of phosphorus-modification of titania supports on the iridium-catalyzed synthesis of benzimidazoles
Yu, Han,Wada, Kenji,Fukutake, Tatsuhiro,Feng, Qi,Uemura, Shinobu,Isoda, Kyosuke,Hirai, Tomomi,Iwamoto, Shinji
, p. 410 - 417 (2021)
Modification of titania supports for iridium catalysts by phosphorus species greatly enhanced the activity for the synthesis of benzimidazoles via hydrogen transfer. Two series of phosphorus-modified titanias were used: The iridium catalysts supported on phosphorus-doped rutile titania prepared by the hydrothermal method showed nearly 5 times higher activity for the reaction of 2-nitroaniline (1a) and benzyl alcohol (2a) to 2-phenylbenzimidazole (3aa) than the catalysts supported on unmodified rutile. XPS depth profile study substantiated that the dopant was present mainly on the surface of the rutile support. Therefore, a facile wet impregnation method was applied to modify the surface of anatase titania with phosphoric acid. The use of thus-modified titania enhanced the activity of the iridium catalysts by more than 2.7 times. The FTIR and XPS studies revealed the presence of bidentate phosphorus species on the surface of titania, and the H2-TPR study indicated that phosphorus-modification promoted the formation of iridium species reduced at higher temperature, which would be suitable for the present catalysis.
DNA binding, crystal structure, molecular docking studies and anticancer activity evaluation of a copper(II) complex
Liu, Ya-Xian,Mo, Hui-Wen,Lv, Zhen-Yu,Shen, Fang,Zhang, Chun-Lian,Qi, Yong-Yu,Mao, Zong-Wan,Le, Xue-Yi
, p. 259 - 271 (2018)
A copper complex [Cu(HPBM)(l-Phe)(H2O)]·ClO4(1) (HPBM?=?5-methyl-2-(2′-pyridyl)benzimidazole, l-Phe?=?l-phenylalanine anion) was synthesized and characterized by elemental analysis, IR, ESI–MS, HR–ESI–MS, ESR spectroscopy, and by X-ray single-crystal analysis. The binding constant of the complex with calf thymus DNA (CT-DNA) was determined as 7.38 (±?0.57)?×?104?M?1. Further studies indicated that the complex interacts with CT-DNA through minor groove binding. The in vitro cytotoxic activities of both the free proligand and the complex against Eca-109, HeLa and A549 cancer cells and normal LO2 cells were evaluated by the MTT method. The IC50 values range from 5.7?±?0.1 to 8.3?±?0.6?μM. Free HPBM displays no cytotoxic activity against the selected cancer cells, with IC50 values more than 100?μM. Double staining analysis showed that the complex can induce apoptosis in Eca-109 cells. Comet assays demonstrated that the complex can damage DNA and cause apoptosis. The complex also induces an increase in intracellular reactive oxygen species and a reduction in mitochondrial membrane potential. The complex can also increase the intracellular Ca2+ level and induce release of cytochrome c. The cell cycle arrest was investigated by flow cytometry. The results demonstrate that the complex induces apoptosis in Eca-109 cells through DNA-binding and ROS-mediated mitochondrial dysfunctional pathways.
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Moriarty et al.
, p. 5959 (1967)
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Taylor,McKillop
, p. 2858 (1965)
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1-Methylimidazolium ionic liquid supported on Ni@zeolite-Y: fabrication and performance as a novel multi-functional nanocatalyst for one-pot synthesis of 2-aminothiazoles and 2-aryl benzimidazoles
Kalhor, Mehdi,Zarnegar, Zohre
, p. 519 - 540 (2021/12/03)
In the present study, 1-methyl-3-(3-trimethoxysilylpropyl)-1H-imidazol-3-ium chloride-supported Ni@zeolite-Y-based nanoporous materials (Ni@zeolite-Im-IL) were synthesized and their structures were confirmed using different characterization techniques such as FT-IR, FE-SEM, EDX, XRD, BET and TGA-DTG analyses. In order to synthesize this multi-functional nano-system, zeolite-NaY was modified first, with exchanged Ni2+ ions and 3-chloropropyltriethoxysilane (CPTES) as a coupling reagent and then functionalized to imidazolium chloride ionic liquid by N-methylimidazole. New multi-functional nano-material of Ni@zeolite-Im-IL demonstrated high activity in the catalytic synthesis of 2-aminothiazoles 3a–l by one-pot reaction of methylcarbonyls, thiourea and iodine at 80?°C in DMSO with good to excellent yields (85–98%). Also, the catalytic synthesis of 2-aryl benzimidazoles, 6a–m was performed by the condensational reaction of o-arylendiamine and aromatic aldehydes in EtOH at room temperature with excellent yields (90–98%). Advantages of this efficient synthetic strategy include higher purity and shorter reaction time, excellent yield, easy isolation of products, the good stability, activity and feasible reusability of the metallic ionic liquid nanocatalyst. These benefits have made this method more compatible with the principles of green chemistry. Graphical abstract: [Figure not available: see fulltext.]
Coordination-driven reversible supramolecular assembly formation at biological pH: Trace-level detection of Hg2+ and I? ions in real life samples
Dey, Nilanjan
, (2021/10/26)
Pyridine coupled bisbenzimidazole probe has been developed for colorimetric sensing of heavy metal pollutants in the aqueous medium. Mechanistic investigation indicates that Hg2+ ions (detection limit: 7.5 ppb) bind to the pyridyl nitrogen ends
